Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 2385908..2386279 | Replicon | chromosome |
| Accession | NZ_CP080233 | ||
| Organism | Escherichia coli O139:H1 strain P15-25 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | A0A839BBC2 |
| Locus tag | KZW90_RS11615 | Protein ID | WP_021500490.1 |
| Coordinates | 2386085..2386279 (-) | Length | 65 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 2385908..2386086 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZW90_RS11590 (2381863) | 2381863..2383236 | + | 1374 | WP_063085924.1 | ATP-dependent RNA helicase DbpA | - |
| KZW90_RS11595 (2383365) | 2383365..2384300 | - | 936 | WP_001157382.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| KZW90_RS11600 (2384352) | 2384352..2385587 | - | 1236 | WP_024168543.1 | site-specific integrase | - |
| KZW90_RS11605 (2385589) | 2385589..2385804 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (2385908) | 2385908..2386086 | + | 179 | NuclAT_1 | - | Antitoxin |
| - (2385908) | 2385908..2386086 | + | 179 | NuclAT_1 | - | Antitoxin |
| - (2385908) | 2385908..2386086 | + | 179 | NuclAT_1 | - | Antitoxin |
| - (2385908) | 2385908..2386086 | + | 179 | NuclAT_1 | - | Antitoxin |
| KZW90_RS11610 (2385904) | 2385904..2386092 | - | 189 | WP_001372676.1 | DUF1187 family protein | - |
| KZW90_RS11615 (2386085) | 2386085..2386279 | - | 195 | WP_021500490.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| KZW90_RS11620 (2386343) | 2386343..2387395 | - | 1053 | WP_001004412.1 | RecT family recombinase | - |
| KZW90_RS11625 (2387407) | 2387407..2390529 | - | 3123 | WP_000105090.1 | exodeoxyribonuclease VIII | - |
| KZW90_RS11630 (2390629) | 2390629..2390904 | - | 276 | WP_001372690.1 | hypothetical protein | - |
| KZW90_RS11635 (2390979) | 2390979..2391149 | - | 171 | WP_065336296.1 | YdaE family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2384352..2408763 | 24411 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7046.98 Da Isoelectric Point: 9.2886
>T211289 WP_021500490.1 NZ_CP080233:c2386279-2386085 [Escherichia coli O139:H1]
MRYEKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
MRYEKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
Download Length: 195 bp
>T211289 NZ_CP104835:c5955294-5954032 [Achromobacter xylosoxidans]
ATGAGCACCGACGCGCTCGATCTCTACCAGGCGGATCGCAAGGTCGGCCGCCTGTTCGACGAACGGCCCTTGCGGTTCGT
CTATGACGACGCCTGGCTGGGATGGCCCGCGGCGCACGCCATCGCGCCGGACATCCCGCTGCGCGACGGCGCTCATGTCG
GCGAGGCCGTGCATGCCTTCTTCGAAAACCTGCTGCCCGAAGGGCGCCTGCGTCGATTCCTGCAAGTCAGCCGCCACGCA
ACGACCGTCTTCGGTCTGCTGCGCAGTGTCGGGGGCGACACGGCGAGCGGTCTGACGATATGGCCACAAGGCGAACGGCC
GGCGCCGCCGCGCTATCGCGGCACGACCTGGGGCGAGATCGTCGCGCGTTTACAGGATCCGGCGCAGCCGGCCCTTGTCG
CCGAGAATGCCGACGGCGCGCGTATTTCACTGGCGGGCGCGCAGGACAAGCTGCTGCTGATGGTCATGCCGGATGGCTCG
CCGGCCTGGCCCGAAGGCGCCGCGCCCTCCACGCACATTCTCAAGCCGGACATTCGCGGTTTTGATGGCGTCTGGTCATC
GGCGCTCAATGAAACCCTGGTGATGCAATTGGCGGCGCGGCTGGGGCTCGGCGTGGCCGAGGCAGGCCTGCAACCGGATA
CCCGCGCGTGCCTGGTCACCCGCTACGATCGCGCGCCGGACGGCGCGGGGGGCCTGCTGCGCCTGCATCAGCTCGATCTG
TGCCAACTGGCAGGCAAGTCCTCGGACGTGAAATACGAAGCCGATGGCGGACCGTCGCTGGCGCATTGCCGCGAACTGCT
CCGGGGCATGGGCATCAACGCGGCGGATCTCAAGCGGTTCCTGCAGTGGGTGCTGTTCAACCTTTGCGTCGGCAATAACG
ACAGCCATGCCAAGAACCTGTCCGTGCTGCAAACGCCGGATGGCCAGTACCGCCTGGCGCCGTTCTATGACCTGATGTGT
ACCGCGCTGTATCCCGGCCTGGCCCGCAATTTCGCGTTTGCCGTGGGAGGAGAATCCAGGCCGGGCCACATCGGCCGCGG
ACACCTGGATGCGATGGCCCGGGAACTGGGCTTCAGCCCCCGTTATGTGGCCGGCATGGCGCAGGCGCTGGTGACGGAAT
TGCCGTCGGCGCTGGAAACGGTGCAGGCCGACCTGGCGCGGCAGGCCATGGCAGGAACGGAAAGCACGCTGGTCGAGCGT
CTGGGCCAGTGGATCCGGGCCAATACCCGCAAGCATGCCAAACGCTGGGAACTGGCGGGCTGA
ATGAGCACCGACGCGCTCGATCTCTACCAGGCGGATCGCAAGGTCGGCCGCCTGTTCGACGAACGGCCCTTGCGGTTCGT
CTATGACGACGCCTGGCTGGGATGGCCCGCGGCGCACGCCATCGCGCCGGACATCCCGCTGCGCGACGGCGCTCATGTCG
GCGAGGCCGTGCATGCCTTCTTCGAAAACCTGCTGCCCGAAGGGCGCCTGCGTCGATTCCTGCAAGTCAGCCGCCACGCA
ACGACCGTCTTCGGTCTGCTGCGCAGTGTCGGGGGCGACACGGCGAGCGGTCTGACGATATGGCCACAAGGCGAACGGCC
GGCGCCGCCGCGCTATCGCGGCACGACCTGGGGCGAGATCGTCGCGCGTTTACAGGATCCGGCGCAGCCGGCCCTTGTCG
CCGAGAATGCCGACGGCGCGCGTATTTCACTGGCGGGCGCGCAGGACAAGCTGCTGCTGATGGTCATGCCGGATGGCTCG
CCGGCCTGGCCCGAAGGCGCCGCGCCCTCCACGCACATTCTCAAGCCGGACATTCGCGGTTTTGATGGCGTCTGGTCATC
GGCGCTCAATGAAACCCTGGTGATGCAATTGGCGGCGCGGCTGGGGCTCGGCGTGGCCGAGGCAGGCCTGCAACCGGATA
CCCGCGCGTGCCTGGTCACCCGCTACGATCGCGCGCCGGACGGCGCGGGGGGCCTGCTGCGCCTGCATCAGCTCGATCTG
TGCCAACTGGCAGGCAAGTCCTCGGACGTGAAATACGAAGCCGATGGCGGACCGTCGCTGGCGCATTGCCGCGAACTGCT
CCGGGGCATGGGCATCAACGCGGCGGATCTCAAGCGGTTCCTGCAGTGGGTGCTGTTCAACCTTTGCGTCGGCAATAACG
ACAGCCATGCCAAGAACCTGTCCGTGCTGCAAACGCCGGATGGCCAGTACCGCCTGGCGCCGTTCTATGACCTGATGTGT
ACCGCGCTGTATCCCGGCCTGGCCCGCAATTTCGCGTTTGCCGTGGGAGGAGAATCCAGGCCGGGCCACATCGGCCGCGG
ACACCTGGATGCGATGGCCCGGGAACTGGGCTTCAGCCCCCGTTATGTGGCCGGCATGGCGCAGGCGCTGGTGACGGAAT
TGCCGTCGGCGCTGGAAACGGTGCAGGCCGACCTGGCGCGGCAGGCCATGGCAGGAACGGAAAGCACGCTGGTCGAGCGT
CTGGGCCAGTGGATCCGGGCCAATACCCGCAAGCATGCCAAACGCTGGGAACTGGCGGGCTGA
Antitoxin
Download Length: 179 bp
>AT211289 NZ_CP080233:2385908-2386086 [Escherichia coli O139:H1]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCCGATTTGGTTAACTTTGTTTTTGAGTACCTTGTCCAGCTGGTAGGAGAACCACCTTCCTTTT
CAATAGTGGCGGTGATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCCGATTTGGTTAACTTTGTTTTTGAGTACCTTGTCCAGCTGGTAGGAGAACCACCTTCCTTTT
CAATAGTGGCGGTGATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
