Detailed information of TA system TA211242

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2569444..2569967
• Replicon: chromosome
• Accession: NZ_CP080222
• Organism: Staphylococcus aureus strain NT_8

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YCD0
• Locus tag: KZW87_RS13030
• Protein ID: WP_000074043.1
• Coordinates: 2569444..2569710 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: KZW87_RS13035
• Protein ID: WP_000587618.1
• Coordinates: 2569710..2569967 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZW87_RS13010 (KZW87_12960)	2564750..2565937	-	1188	WP_000026194.1	MFS transporter	-
KZW87_RS13015 (KZW87_12965)	2566333..2567109	-	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
KZW87_RS13020 (KZW87_12970)	2567102..2567764	-	663	WP_000923524.1	ATP-binding cassette domain-containing protein	-
KZW87_RS13025 (KZW87_12975)	2568012..2569088	-	1077	WP_001076673.1	M42 family metallopeptidase	-
KZW87_RS13030 (KZW87_12980)	2569444..2569710	-	267	WP_000074043.1	Txe/YoeB family addiction module toxin	Toxin
KZW87_RS13035 (KZW87_12985)	2569710..2569967	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KZW87_RS13040 (KZW87_12990)	2570326..2570781	+	456	WP_000732076.1	DUF1307 domain-containing protein	-
KZW87_RS13045 (KZW87_12995)	2570949..2572526	-	1578	WP_000143503.1	FMN-binding glutamate synthase family protein	-
KZW87_RS13050 (KZW87_13000)	2572721..2573470	+	750	WP_000072466.1	CPBP family lipoprotein N-acylation protein LnsB	-
KZW87_RS13055 (KZW87_13005)	2573701..2574894	-	1194	WP_000675407.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10657.45 Da
• Isoelectric Point: 10.3584

>T211242 WP_000074043.1 NZ_CP080222:c2569710-2569444 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T211242 NZ_CP104788:c530313-530095 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT211242 WP_000587618.1 NZ_CP080222:c2569967-2569710 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT211242 NZ_CP104788:c530713-530339 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: T1YCD0

Antitoxin

• AlphaFold DB: T1YBB2