211242

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2569444..2569967 Replicon chromosome
Accession NZ_CP080222
Organism Staphylococcus aureus strain NT_8

Toxin (Protein)


Gene name yoeB Uniprot ID T1YCD0
Locus tag KZW87_RS13030 Protein ID WP_000074043.1
Coordinates 2569444..2569710 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag KZW87_RS13035 Protein ID WP_000587618.1
Coordinates 2569710..2569967 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZW87_RS13010 (KZW87_12960) 2564750..2565937 - 1188 WP_000026194.1 MFS transporter -
KZW87_RS13015 (KZW87_12965) 2566333..2567109 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
KZW87_RS13020 (KZW87_12970) 2567102..2567764 - 663 WP_000923524.1 ATP-binding cassette domain-containing protein -
KZW87_RS13025 (KZW87_12975) 2568012..2569088 - 1077 WP_001076673.1 M42 family metallopeptidase -
KZW87_RS13030 (KZW87_12980) 2569444..2569710 - 267 WP_000074043.1 Txe/YoeB family addiction module toxin Toxin
KZW87_RS13035 (KZW87_12985) 2569710..2569967 - 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KZW87_RS13040 (KZW87_12990) 2570326..2570781 + 456 WP_000732076.1 DUF1307 domain-containing protein -
KZW87_RS13045 (KZW87_12995) 2570949..2572526 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
KZW87_RS13050 (KZW87_13000) 2572721..2573470 + 750 WP_000072466.1 CPBP family lipoprotein N-acylation protein LnsB -
KZW87_RS13055 (KZW87_13005) 2573701..2574894 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10657.45 Da        Isoelectric Point: 10.3584

>T211242 WP_000074043.1 NZ_CP080222:c2569710-2569444 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T211242 NZ_CP104788:c530313-530095 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT211242 WP_000587618.1 NZ_CP080222:c2569967-2569710 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT211242 NZ_CP104788:c530713-530339 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T1YCD0

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References