Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2537838..2538022 Replicon chromosome
Accession NZ_CP080222
Organism Staphylococcus aureus strain NT_8

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag KZW87_RS12890 Protein ID WP_000482647.1
Coordinates 2537915..2538022 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2537838..2537898 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZW87_RS12875 (KZW87_12825) 2533368..2533535 - 168 WP_001790576.1 hypothetical protein -
KZW87_RS12880 (KZW87_12830) 2533766..2535499 - 1734 WP_000486494.1 ABC transporter ATP-binding protein -
KZW87_RS12885 (KZW87_12835) 2535524..2537287 - 1764 WP_001064816.1 ABC transporter ATP-binding protein -
- 2537838..2537898 + 61 - - Antitoxin
KZW87_RS12890 (KZW87_12840) 2537915..2538022 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
KZW87_RS12895 (KZW87_12845) 2538156..2538542 - 387 WP_000779360.1 flippase GtxA -
KZW87_RS12900 (KZW87_12850) 2538800..2539942 + 1143 WP_001176863.1 glycerate kinase -
KZW87_RS12905 (KZW87_12855) 2540002..2540661 + 660 WP_000831298.1 membrane protein -
KZW87_RS12910 (KZW87_12860) 2540843..2542054 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
KZW87_RS12915 (KZW87_12865) 2542177..2542650 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T211240 WP_000482647.1 NZ_CP080222:c2538022-2537915 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T211240 NZ_CP104788:c305816-305538 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 61 bp

>AT211240 NZ_CP080222:2537838-2537898 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References