Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2512605..2513122 | Replicon | chromosome |
| Accession | NZ_CP080222 | ||
| Organism | Staphylococcus aureus strain NT_8 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | KZW87_RS12755 | Protein ID | WP_000113262.1 |
| Coordinates | 2512605..2512871 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | KZW87_RS12760 | Protein ID | WP_000584499.1 |
| Coordinates | 2512871..2513122 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZW87_RS12725 (KZW87_12680) | 2508030..2508566 | - | 537 | WP_031585827.1 | GNAT family N-acetyltransferase | - |
| KZW87_RS12730 (KZW87_12685) | 2508799..2509623 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| KZW87_RS12735 (KZW87_12690) | 2509840..2510022 | - | 183 | WP_000230294.1 | hypothetical protein | - |
| KZW87_RS12740 (KZW87_12695) | 2510106..2510573 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| KZW87_RS12745 (KZW87_12700) | 2510759..2512309 | - | 1551 | WP_000727763.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| KZW87_RS12750 | 2512493..2512570 | - | 78 | Protein_2475 | hypothetical protein | - |
| KZW87_RS12755 (KZW87_12705) | 2512605..2512871 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| KZW87_RS12760 (KZW87_12710) | 2512871..2513122 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KZW87_RS12765 (KZW87_12715) | 2513287..2513388 | - | 102 | WP_031774922.1 | hypothetical protein | - |
| KZW87_RS12770 (KZW87_12720) | 2513395..2513994 | - | 600 | WP_000162813.1 | DsbA family protein | - |
| KZW87_RS12775 (KZW87_12725) | 2514013..2514375 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| KZW87_RS12780 (KZW87_12730) | 2514630..2515880 | + | 1251 | WP_001012223.1 | FemA/FemB family glycyltransferase FmhA | - |
| KZW87_RS12785 (KZW87_12735) | 2515977..2516708 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| KZW87_RS12790 (KZW87_12740) | 2516705..2517424 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T211239 WP_000113262.1 NZ_CP080222:c2512871-2512605 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T211239 NZ_CP104787:54914-55273 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT211239 WP_000584499.1 NZ_CP080222:c2513122-2512871 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT211239 NZ_CP104787:55273-55572 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTCTCGAACTTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCGATATCTATTTAA
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTCTCGAACTTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCGATATCTATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|