Detailed information of TA system TA211238

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-sprA1AS/-
• Location: 2254372..2254569
• Replicon: chromosome
• Accession: NZ_CP080222
• Organism: Staphylococcus aureus strain NT_8

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KZW87_RS11395
• Protein ID: WP_001802298.1
• Coordinates: 2254465..2254569 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2254372..2254410 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZW87_RS11370 (KZW87_11335)	2250547..2251212	-	666	WP_001024095.1	SDR family oxidoreductase	-
KZW87_RS11375 (KZW87_11340)	2251364..2251684	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KZW87_RS11380 (KZW87_11345)	2251686..2252666	+	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
KZW87_RS11385 (KZW87_11350)	2252932..2254023	+	1092	WP_000495681.1	hypothetical protein	-
KZW87_RS11390	2254352..2254426	+	75	Protein_2213	hypothetical protein	-
-	2254372..2254410	+	39	-	-	Antitoxin
KZW87_RS11395 (KZW87_11355)	2254465..2254569	-	105	WP_001802298.1	hypothetical protein	Toxin
KZW87_RS11400 (KZW87_11360)	2255086..2255256	+	171	WP_001792292.1	transposase	-
KZW87_RS11405 (KZW87_11365)	2255249..2255407	+	159	WP_001792784.1	hypothetical protein	-
KZW87_RS11410 (KZW87_11370)	2256065..2256922	-	858	WP_000370930.1	HAD family hydrolase	-
KZW87_RS11415 (KZW87_11375)	2256990..2257772	-	783	WP_031590911.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T211238 WP_001802298.1 NZ_CP080222:c2254569-2254465 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T211238 NZ_CP104786:255668-256057 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Nucleotide

• Length: 39 bp

>AT211238 NZ_CP080222:2254372-2254410 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin