Detailed information of TA system TA211233

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1971258..1971438
• Replicon: chromosome
• Accession: NZ_CP080222
• Organism: Staphylococcus aureus strain NT_8

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: KZW87_RS09795
• Protein ID: WP_001801861.1
• Coordinates: 1971258..1971353 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1971381..1971438 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZW87_RS09770 (KZW87_09740)	1967313..1967939	+	627	WP_000669028.1	hypothetical protein	-
KZW87_RS09775 (KZW87_09745)	1968026..1968709	+	684	WP_000957233.1	exotoxin beta-grasp domain-containing protein	-
KZW87_RS09780 (KZW87_09750)	1968736..1969488	+	753	WP_000764922.1	staphylococcal enterotoxin type 27	-
KZW87_RS09785 (KZW87_09755)	1969620..1970246	-	627	Protein_1935	ImmA/IrrE family metallo-endopeptidase	-
KZW87_RS09790 (KZW87_09760)	1970360..1970806	-	447	WP_000747805.1	DUF1433 domain-containing protein	-
KZW87_RS09795 (KZW87_09765)	1971258..1971353	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1971381..1971438	-	58	-	-	Antitoxin
KZW87_RS09800	1971476..1971574	+	99	Protein_1938	hypothetical protein	-
KZW87_RS09805	1972004..1972267	-	264	WP_226340588.1	hypothetical protein	-
KZW87_RS09810 (KZW87_09775)	1972686..1973858	+	1173	WP_000195429.1	IS256-like element IS256 family transposase	-
KZW87_RS09815 (KZW87_09780)	1973829..1974590	-	762	WP_224684922.1	DNA adenine methylase	-
KZW87_RS09820 (KZW87_09785)	1974629..1975894	-	1266	WP_031796962.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk	1964754..1994113	29359
	-	flank	IS/Tn	-	-	1972686..1973858	1172

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T211233 WP_001801861.1 NZ_CP080222:1971258-1971353 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T211233 NZ_CP104766:c4839014-4838730 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT211233 NZ_CP080222:c1971438-1971381 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin