Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) TMCS/-
Location 1632104..1632683 Replicon chromosome
Accession NZ_CP080222
Organism Staphylococcus aureus strain NT_8

Toxin (Protein)


Gene name MW1434 Uniprot ID A0A4P7P609
Locus tag KZW87_RS08095 Protein ID WP_001025401.1
Coordinates 1632438..1632683 (-) Length 82 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 1632104..1632469 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZW87_RS08035 (KZW87_08005) 1627644..1628000 - 357 WP_001132243.1 hypothetical protein -
KZW87_RS08040 (KZW87_08010) 1628000..1628752 - 753 WP_031584871.1 DnaD domain protein -
KZW87_RS08045 (KZW87_08015) 1628745..1629419 - 675 WP_031584874.1 putative HNHc nuclease -
KZW87_RS08050 (KZW87_08020) 1629433..1629861 - 429 WP_031584877.1 single-stranded DNA-binding protein -
KZW87_RS08055 (KZW87_08025) 1629861..1630484 - 624 WP_000139720.1 DUF1071 domain-containing protein -
KZW87_RS08060 (KZW87_08030) 1630477..1630698 - 222 WP_000815401.1 DUF2483 family protein -
KZW87_RS08065 (KZW87_08035) 1630708..1630968 - 261 WP_031584888.1 DUF1108 family protein -
KZW87_RS08070 (KZW87_08040) 1630973..1631275 - 303 WP_001608484.1 DUF2482 family protein -
KZW87_RS08075 (KZW87_08045) 1631370..1631531 - 162 WP_001285948.1 DUF1270 domain-containing protein -
KZW87_RS08080 (KZW87_08050) 1631544..1631807 - 264 WP_001124196.1 helix-turn-helix domain-containing protein -
KZW87_RS08085 (KZW87_08055) 1631834..1632049 - 216 WP_001097552.1 hypothetical protein -
KZW87_RS08090 (KZW87_08060) 1632104..1632469 + 366 WP_001128433.1 hypothetical protein Antitoxin
KZW87_RS08095 (KZW87_08065) 1632438..1632683 - 246 WP_001025401.1 DUF2829 domain-containing protein Toxin
KZW87_RS08100 (KZW87_08070) 1632750..1633130 + 381 WP_000773059.1 DUF2513 domain-containing protein -
KZW87_RS08105 (KZW87_08075) 1633117..1633314 - 198 WP_001148860.1 hypothetical protein -
KZW87_RS08110 1633384..1633674 + 291 WP_094321613.1 uracil-DNA glycosylase -
KZW87_RS08115 (KZW87_08085) 1633664..1633807 - 144 WP_000939498.1 hypothetical protein -
KZW87_RS08120 (KZW87_08090) 1633836..1634612 - 777 WP_031914835.1 Rha family transcriptional regulator -
KZW87_RS08125 (KZW87_08095) 1634626..1634871 - 246 WP_094314651.1 helix-turn-helix transcriptional regulator -
KZW87_RS08130 (KZW87_08100) 1635063..1635392 + 330 WP_001573842.1 helix-turn-helix transcriptional regulator -
KZW87_RS08135 (KZW87_08105) 1635405..1635866 + 462 WP_000525004.1 hypothetical protein -
KZW87_RS08140 (KZW87_08110) 1635884..1636468 + 585 WP_000825948.1 hypothetical protein -
KZW87_RS08145 (KZW87_08115) 1636698..1636844 + 147 WP_113342690.1 hypothetical protein -
KZW87_RS08150 (KZW87_08120) 1636841..1637455 - 615 WP_001636974.1 phage protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1592913..1651538 58625


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF2829

(2-69)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9468.72 Da        Isoelectric Point: 5.7783

>T211229 WP_001025401.1 NZ_CP080222:c1632683-1632438 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Download         Length: 246 bp

>T211229 NZ_CP104766:c2754189-2752867 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTACTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCTACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 366 bp

>AT211229 NZ_CP080222:1632104-1632469 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7P609

Antitoxin

Download structure file

References