Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-couple_hipB
Location 23498..24168 Replicon chromosome
Accession NZ_CP080203
Organism Mycetocola spongiae strain MSC19

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag KXZ72_RS00130 Protein ID WP_226081688.1
Coordinates 23498..23863 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag KXZ72_RS00135 Protein ID WP_226081689.1
Coordinates 23863..24168 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXZ72_RS00105 (KXZ72_00105) 19049..19957 + 909 WP_226081684.1 bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase -
KXZ72_RS00110 (KXZ72_00110) 20094..21872 + 1779 WP_226081685.1 AIPR family protein -
KXZ72_RS00115 (KXZ72_00115) 22042..22197 + 156 Protein_22 DNA-formamidopyrimidine glycosylase -
KXZ72_RS00120 (KXZ72_00120) 22290..22691 + 402 WP_226081686.1 DUF1622 domain-containing protein -
KXZ72_RS00125 (KXZ72_00125) 22775..23266 - 492 WP_226081687.1 hypothetical protein -
KXZ72_RS00130 (KXZ72_00130) 23498..23863 + 366 WP_226081688.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KXZ72_RS00135 (KXZ72_00135) 23863..24168 + 306 WP_226081689.1 helix-turn-helix transcriptional regulator Antitoxin
KXZ72_RS00140 (KXZ72_00140) 24278..24757 + 480 WP_226081690.1 hypothetical protein -
KXZ72_RS00145 (KXZ72_00145) 24821..25537 - 717 WP_226081691.1 DUF6226 family protein -
KXZ72_RS00150 (KXZ72_00150) 25549..26352 - 804 WP_226081692.1 tyrosine-protein phosphatase -
KXZ72_RS00155 (KXZ72_00155) 26475..27242 + 768 WP_226081693.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13833.75 Da        Isoelectric Point: 7.2788

>T211227 WP_226081688.1 NZ_CP080203:23498-23863 [Mycetocola spongiae]
MWEVDLALIEGWLLSLDDDSYAQVLAAVELLEECGPRLGRPLVDTVKTSTHKNMKELRPGSSGRSALRVLFAFDPQRRAI
MLIAGDKSGNWKSWYRKNIPAADELFDRHLHQQKNNRGEWS

Download         Length: 366 bp

>T211227 NZ_CP104766:1986223-1986325 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11584.35 Da        Isoelectric Point: 10.0276

>AT211227 WP_226081689.1 NZ_CP080203:23863-24168 [Mycetocola spongiae]
MPLTREQLLARRPVESERIEAHKERMLGEVRSYRLRELREAAGLTQSDLAERIGVGQRQISKIERGDLDNTKIGTIRKYL
AAVGGDLSMEYIIGERRLHLV

Download         Length: 306 bp

>AT211227 NZ_CP104766:c1986332-1986187 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References