Detailed information of TA system TA211160

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4823872..4824130
• Replicon: chromosome
• Accession: NZ_CP080163
• Organism: Escherichia coli strain PK8275

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: KZY08_RS23090
• Protein ID: WP_000809168.1
• Coordinates: 4823978..4824130 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4823872..4823929 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZY08_RS23075	4820264..4821223	+	960	WP_000871674.1	hypothetical protein	-
KZY08_RS23080	4821261..4822160	-	900	WP_001300855.1	transcriptional activator NhaR	-
KZY08_RS23085	4822226..4823392	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	4823872..4823929	-	58	-	-	Antitoxin
KZY08_RS23090	4823978..4824130	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
KZY08_RS23095	4824234..4825364	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
KZY08_RS23100	4825453..4827369	-	1917	WP_000516135.1	molecular chaperone DnaK	-
KZY08_RS23105	4827745..4828149	+	405	WP_000843584.1	DUF2541 family protein	-
KZY08_RS23110	4828175..4828888	+	714	WP_001102367.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T211160 WP_000809168.1 NZ_CP080163:4823978-4824130 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T211160 NZ_CP104727:2051611-2052180 [Pseudomonas citronellolis]
ATGTTCAGACCGTCACCCATCACCCTGCAGCGCGGTGCGCTGCGCCTGGAGCCCATGGTCGAGGCCGACGTGCCGGACCT
GGTGGCGCTGGCCGAGGCCAATCGCGAGGCGCTGAGGTTCATGAGCGCGCCGCAGCGCCCGGACTGGTACCGCAACAGCC
TCGCCGAGCAGCGCGAGGGCCGCGCCCTGCCGCTGGTGGTGCGCCTGGGCAACCAACTGGTGGGCACCACCCGCTTCATG
GACTTCCTCCCGGCGCTGCCGGCCTGCGAGATCGGCGGCACCTGGCTGGACGCGGCGCAGCACGGCACCGGGCTGAACGC
CAGCATCAAGTACCTGATGCTGCGCCAGGCTTTCGACAACTGGAAGATGGTCCGCGTGCAACTGAAGACCGCCGCCAGCA
ACCTGCGCTCGCAGCGCGCCATCGAGAAGCTCGGCGCGGTGCGCGAGGGCGTGCTGCGCAACCACCGGCGCCTGGCCGGC
GGGCGCCTGGACGACAGCGTTCTCTACAGCATCACCGACCTGGAGTGGCCGCAGGTGAAGGCCGCCCTGGAAGCCGGCTT
CATCGGCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT211160 NZ_CP080163:c4823929-4823872 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin