Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 332678..333270 Replicon chromosome
Accession NC_006371
Organism Photobacterium profundum SS9

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PBPR_RS19800 Protein ID WP_041395644.1
Coordinates 332678..332998 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PBPR_RS19805 Protein ID WP_011220380.1
Coordinates 332995..333270 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PBPR_RS19775 328948..329715 + 768 WP_011220375.1 TerC family protein -
PBPR_RS19780 329836..330441 + 606 WP_011220376.1 IS110 family transposase -
PBPR_RS19790 330413..331986 + 1574 WP_086000069.1 IS3 family transposase -
PBPR_RS19795 332026..332346 + 321 Protein_290 IS200/IS605 family transposase -
PBPR_RS19800 332678..332998 + 321 WP_041395644.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PBPR_RS19805 332995..333270 + 276 WP_011220380.1 helix-turn-helix transcriptional regulator Antitoxin
PBPR_RS19810 333366..333662 + 297 WP_011218334.1 IS66 family insertion sequence hypothetical protein -
PBPR_RS19815 333662..334009 + 348 WP_011218059.1 IS66 family insertion sequence element accessory protein TnpB -
PBPR_RS19820 334118..335662 + 1545 WP_041394898.1 IS66 family transposase -
PBPR_RS19825 336127..336423 + 297 WP_011220382.1 BrnT family toxin -
PBPR_RS19830 336401..336625 + 225 WP_197535880.1 BrnA antitoxin family protein -
PBPR_RS19835 336676..338064 - 1389 WP_011220383.1 IS4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 330413..342105 11692
- inside IScluster/Tn - - 330413..340153 9740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12109.31 Da        Isoelectric Point: 9.9270

>T21115 WP_041395644.1 NC_006371:332678-332998 [Photobacterium profundum SS9]
MAWKVDFYSGVEDEILSMPPKIQARMIKLLELIELYGANLGPPHTNSMGDGLFEIRAKAQEGIGRGLFCYLKGQHVYVLR
AFVKKSNKTPKKEIELARERMKEVKL

Download         Length: 321 bp

>T21115 NC_006371:332678-332998 [Photobacterium profundum SS9]
ATGGCTTGGAAAGTGGACTTTTACTCAGGTGTAGAAGATGAAATATTATCTATGCCACCTAAGATTCAAGCTCGCATGAT
TAAATTACTCGAATTGATTGAGTTATATGGAGCAAATCTAGGTCCACCGCATACAAACTCTATGGGTGATGGTCTTTTTG
AAATAAGAGCTAAGGCTCAAGAAGGTATAGGTAGAGGGTTGTTTTGCTATTTAAAAGGACAGCACGTTTACGTATTAAGG
GCCTTTGTGAAAAAGTCGAATAAGACTCCAAAGAAAGAAATAGAGTTGGCAAGAGAGAGAATGAAAGAGGTGAAATTATG
A

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9947.35 Da        Isoelectric Point: 6.9789

>AT21115 WP_011220380.1 NC_006371:332995-333270 [Photobacterium profundum SS9]
MSLSALKKNALQNPEVKKAYDDLGAEFELISSLITMREESGLTQDEVAERMGTKAPNISRLESGRSNPSLKTLVSYAQAC
GFKLDLGFKHA

Download         Length: 276 bp

>AT21115 NC_006371:332995-333270 [Photobacterium profundum SS9]
ATGAGTTTATCTGCATTAAAAAAGAATGCTCTTCAGAATCCAGAAGTAAAGAAAGCTTATGATGATTTAGGTGCTGAGTT
TGAGTTGATTAGTTCTTTGATAACGATGAGAGAAGAGTCAGGGTTAACTCAAGATGAGGTCGCCGAAAGAATGGGGACAA
AAGCTCCGAATATTTCCCGTTTGGAATCCGGCCGATCAAATCCCAGCCTTAAAACGTTAGTTAGTTATGCCCAAGCATGC
GGGTTTAAACTAGATCTAGGCTTCAAACATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References