211142

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1385878..1386571 Replicon chromosome
Accession NZ_CP080163
Organism Escherichia coli strain PK8275

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KZY08_RS06735 Protein ID WP_000415584.1
Coordinates 1385878..1386174 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KZY08_RS06740 Protein ID WP_000650107.1
Coordinates 1386176..1386571 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY08_RS06700 (1380957) 1380957..1381271 - 315 WP_000958598.1 putative quinol monooxygenase -
KZY08_RS06705 (1381302) 1381302..1381883 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KZY08_RS06710 (1382211) 1382211..1382543 + 333 WP_000917684.1 DUF2645 family protein -
KZY08_RS06715 (1382589) 1382589..1383938 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KZY08_RS06720 (1383935) 1383935..1384594 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KZY08_RS06725 (1384746) 1384746..1385138 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KZY08_RS06730 (1385191) 1385191..1385673 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KZY08_RS06735 (1385878) 1385878..1386174 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KZY08_RS06740 (1386176) 1386176..1386571 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KZY08_RS06745 (1386704) 1386704..1388311 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KZY08_RS06750 (1388449) 1388449..1390707 + 2259 WP_022646133.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T211142 WP_000415584.1 NZ_CP080163:1385878-1386174 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T211142 NZ_CP104721:3796919-3797197 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT211142 WP_000650107.1 NZ_CP080163:1386176-1386571 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT211142 NZ_CP104721:3796656-3796916 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References