Detailed information of TA system TA211116

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4215288..4215546
• Replicon: chromosome
• Accession: NZ_CP080155
• Organism: Escherichia coli strain PK8261

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: KZY07_RS20230
• Protein ID: WP_000809168.1
• Coordinates: 4215394..4215546 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4215288..4215345 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZY07_RS20215	4211680..4212639	+	960	WP_000871674.1	hypothetical protein	-
KZY07_RS20220	4212677..4213576	-	900	WP_001300855.1	transcriptional activator NhaR	-
KZY07_RS20225	4213642..4214808	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	4215288..4215345	-	58	-	-	Antitoxin
KZY07_RS20230	4215394..4215546	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
KZY07_RS20235	4215650..4216780	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
KZY07_RS20240	4216869..4218785	-	1917	WP_000516135.1	molecular chaperone DnaK	-
KZY07_RS20245	4219161..4219565	+	405	WP_000843584.1	DUF2541 family protein	-
KZY07_RS20250	4219591..4220304	+	714	WP_001102367.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T211116 WP_000809168.1 NZ_CP080155:4215394-4215546 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T211116 NZ_CP104698:3268940-3269326 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTTATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT211116 NZ_CP080155:c4215345-4215288 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin