Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
Location | 670708..671507 | Replicon | chromosome |
Accession | NZ_CP080155 | ||
Organism | Escherichia coli strain PK8261 |
Toxin (Protein)
Gene name | yhaV | Uniprot ID | B7NDB6 |
Locus tag | KZY07_RS03340 | Protein ID | WP_000347269.1 |
Coordinates | 670708..671172 (-) | Length | 155 a.a. |
Antitoxin (Protein)
Gene name | prlF | Uniprot ID | V0YUB5 |
Locus tag | KZY07_RS03345 | Protein ID | WP_001309780.1 |
Coordinates | 671172..671507 (-) | Length | 112 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KZY07_RS03310 (665709) | 665709..666143 | - | 435 | WP_000948818.1 | PTS galactosamine/N-acetylgalactosamine transporter subunit IIA | - |
KZY07_RS03315 (666161) | 666161..667039 | - | 879 | WP_001295548.1 | PTS N-acetylgalactosamine transporter subunit IID | - |
KZY07_RS03320 (667029) | 667029..667808 | - | 780 | WP_000406214.1 | PTS N-acetylgalactosamine transporter subunit IIC | - |
KZY07_RS03325 (667819) | 667819..668292 | - | 474 | WP_001295547.1 | PTS N-acetylgalactosamine transporter subunit IIB | - |
KZY07_RS03330 (668315) | 668315..669595 | - | 1281 | WP_000681943.1 | tagatose-bisphosphate aldolase subunit KbaZ | - |
KZY07_RS03335 (669844) | 669844..670653 | + | 810 | WP_000072171.1 | aga operon transcriptional regulator AgaR | - |
KZY07_RS03340 (670708) | 670708..671172 | - | 465 | WP_000347269.1 | type II toxin-antitoxin system ribonuclease toxin YhaV | Toxin |
KZY07_RS03345 (671172) | 671172..671507 | - | 336 | WP_001309780.1 | type II toxin-antitoxin system antitoxin PrlF | Antitoxin |
KZY07_RS03350 (671656) | 671656..673227 | - | 1572 | WP_001273738.1 | galactarate dehydratase | - |
KZY07_RS03355 (673602) | 673602..674936 | + | 1335 | WP_000599651.1 | galactarate/glucarate/glycerate transporter GarP | - |
KZY07_RS03360 (674952) | 674952..675722 | + | 771 | WP_001058227.1 | 2-dehydro-3-deoxyglucarate aldolase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 17806.22 Da Isoelectric Point: 9.6924
>T211096 WP_000347269.1 NZ_CP080155:c671172-670708 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTREAEETH
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTREAEETH
Download Length: 465 bp
>T211096 NZ_CP104681:c4234739-4234464 [Escherichia coli]
ATGGAAATTTACTGGACGTTTAAAGCTCAGGATGACCTAGAACGTATCTATCGTTTCGCCCTTCAGTATAGCCGCAAGCA
CGCCGATGACATTTTGGATCGCCTAATTACTGGCTGCGCTGGCCTTACAGCGCATCCGGCAATTGGTGTACATCAGACTC
GTTATGAACCCCGAGAAGTCCGAAAAGTGTTATTTGATGACTATGAGGTTCACTACGAAATCCGTGACAATGATATCCAT
ATCGTGGATCTCTGGCATACAAAAGAAGAACGATAA
ATGGAAATTTACTGGACGTTTAAAGCTCAGGATGACCTAGAACGTATCTATCGTTTCGCCCTTCAGTATAGCCGCAAGCA
CGCCGATGACATTTTGGATCGCCTAATTACTGGCTGCGCTGGCCTTACAGCGCATCCGGCAATTGGTGTACATCAGACTC
GTTATGAACCCCGAGAAGTCCGAAAAGTGTTATTTGATGACTATGAGGTTCACTACGAAATCCGTGACAATGATATCCAT
ATCGTGGATCTCTGGCATACAAAAGAAGAACGATAA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12345.94 Da Isoelectric Point: 4.8616
>AT211096 WP_001309780.1 NZ_CP080155:c671507-671172 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNT
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNT
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE
Download Length: 336 bp
>AT211096 NZ_CP104681:c4234991-4234743 [Escherichia coli]
ATGGGCTCACTGACTAAACAAACCATCAGCGCACAGATACCCGTTGAGTTGGCTGCTGCTGTTGAGAATCTGGCAATTGA
GTTAGATCGCTCTAAAAGCTGGATTATTAAGGAAGCGTTGACCTGTATGCTGGCCGAAAGAGAGCGGCGTCACCAGAGCA
TCCAGGCCGGTCTTGCCGATGTGGATGCGGGTCGCGTGGTGAGCCACTTAGACATGGTGGATTTTGCTAATCGCTTAAAG
AAAGCCTGA
ATGGGCTCACTGACTAAACAAACCATCAGCGCACAGATACCCGTTGAGTTGGCTGCTGCTGTTGAGAATCTGGCAATTGA
GTTAGATCGCTCTAAAAGCTGGATTATTAAGGAAGCGTTGACCTGTATGCTGGCCGAAAGAGAGCGGCGTCACCAGAGCA
TCCAGGCCGGTCTTGCCGATGTGGATGCGGGTCGCGTGGTGAGCCACTTAGACATGGTGGATTTTGCTAATCGCTTAAAG
AAAGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829IY86 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | V0YUB5 |