Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4721884..4722577 Replicon chromosome
Accession NZ_CP080146
Organism Escherichia coli strain PK8276

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KZY06_RS22685 Protein ID WP_000415584.1
Coordinates 4721884..4722180 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KZY06_RS22690 Protein ID WP_000650107.1
Coordinates 4722182..4722577 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY06_RS22650 (4716972) 4716972..4717286 - 315 WP_000958598.1 putative quinol monooxygenase -
KZY06_RS22655 (4717317) 4717317..4717898 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KZY06_RS22660 (4718217) 4718217..4718549 + 333 WP_000917684.1 DUF2645 family protein -
KZY06_RS22665 (4718595) 4718595..4719944 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KZY06_RS22670 (4719941) 4719941..4720600 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KZY06_RS22675 (4720752) 4720752..4721144 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KZY06_RS22680 (4721197) 4721197..4721679 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KZY06_RS22685 (4721884) 4721884..4722180 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KZY06_RS22690 (4722182) 4722182..4722577 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KZY06_RS22695 (4722710) 4722710..4724317 + 1608 WP_058905436.1 ABC transporter substrate-binding protein -
KZY06_RS22700 (4724455) 4724455..4726713 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T211080 WP_000415584.1 NZ_CP080146:4721884-4722180 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T211080 NZ_CP080146:4721884-4722180 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT211080 WP_000650107.1 NZ_CP080146:4722182-4722577 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT211080 NZ_CP080146:4722182-4722577 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References