Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3129120..3129813 Replicon chromosome
Accession NZ_CP080139
Organism Escherichia coli strain PK8241

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KZY05_RS15980 Protein ID WP_000415584.1
Coordinates 3129517..3129813 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KZY05_RS15975 Protein ID WP_000650107.1
Coordinates 3129120..3129515 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY05_RS15965 (3124984) 3124984..3127242 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
KZY05_RS15970 (3127380) 3127380..3128987 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KZY05_RS15975 (3129120) 3129120..3129515 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KZY05_RS15980 (3129517) 3129517..3129813 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KZY05_RS15985 (3130018) 3130018..3130500 - 483 WP_000183505.1 GyrI-like domain-containing protein -
KZY05_RS15990 (3130553) 3130553..3130945 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KZY05_RS15995 (3131097) 3131097..3131756 + 660 WP_032205041.1 quorum sensing response regulator transcription factor QseB -
KZY05_RS16000 (3131753) 3131753..3133102 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KZY05_RS16005 (3133148) 3133148..3133480 - 333 WP_000917684.1 DUF2645 family protein -
KZY05_RS16010 (3133799) 3133799..3134380 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KZY05_RS16015 (3134411) 3134411..3134725 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T211035 WP_000415584.1 NZ_CP080139:c3129813-3129517 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T211035 NZ_CP104665:c3747954-3747652 [Escherichia coli]
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTGTCTGGGAAATTACAGGAATATTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT211035 WP_000650107.1 NZ_CP080139:c3129515-3129120 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT211035 NZ_CP104665:c3747616-3747275 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTACTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAATAATCGTAAACTCACCACTG
AAATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References