Detailed information of TA system TA211017

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1104329..1104700
• Replicon: chromosome
• Accession: NZ_CP080139
• Organism: Escherichia coli strain PK8241

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: F4VC37
• Locus tag: KZY05_RS05895
• Protein ID: WP_001317028.1
• Coordinates: 1104506..1104700 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1104329..1104507 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZY05_RS29730 (1100081)	1100081..1100254	+	174	WP_001296046.1	protein YnaL	-
KZY05_RS05870 (1100284)	1100284..1101657	+	1374	WP_000123737.1	ATP-dependent RNA helicase DbpA	-
KZY05_RS05875 (1101786)	1101786..1102721	-	936	WP_001157406.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
KZY05_RS05880 (1102773)	1102773..1104008	-	1236	Protein_1154	site-specific integrase	-
KZY05_RS05885 (1104010)	1104010..1104225	-	216	WP_000079604.1	excisionase XisR	-
- (1104329)	1104329..1104507	+	179	NuclAT_0	-	Antitoxin
- (1104329)	1104329..1104507	+	179	NuclAT_0	-	Antitoxin
- (1104329)	1104329..1104507	+	179	NuclAT_0	-	Antitoxin
- (1104329)	1104329..1104507	+	179	NuclAT_0	-	Antitoxin
KZY05_RS05890 (1104304)	1104304..1104513	-	210	WP_000276809.1	double-strand break reduction protein RcbA	-
KZY05_RS05895 (1104506)	1104506..1104700	-	195	WP_001317028.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
KZY05_RS05900 (1104757)	1104757..1105566	-	810	WP_000166319.1	recombination protein RecT	-
KZY05_RS05905 (1105559)	1105559..1108159	-	2601	WP_024232464.1	exodeoxyribonuclease VIII	-
KZY05_RS05910 (1108261)	1108261..1108536	-	276	WP_000632297.1	protein RacC	-
KZY05_RS05915 (1108611)	1108611..1108781	-	171	WP_001352098.1	YdaE family protein	-
KZY05_RS05920 (1108781)	1108781..1109002	-	222	WP_000560223.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1095514..1168555	73041

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7018.89 Da
• Isoelectric Point: 8.9538

>T211017 WP_001317028.1 NZ_CP080139:c1104700-1104506 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T211017 NZ_CP104660:c4981675-4980758 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCTAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAGTCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Nucleotide

• Length: 179 bp

>AT211017 NZ_CP080139:1104329-1104507 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7L6LHV7

Antitoxin