210996

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1793361..1793863 Replicon chromosome
Accession NZ_CP080133
Organism Escherichia coli strain PK8277

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag KZY04_RS08575 Protein ID WP_000767829.1
Coordinates 1793609..1793863 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag KZY04_RS08570 Protein ID WP_001259255.1
Coordinates 1793361..1793612 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY04_RS08545 (1788539) 1788539..1789606 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
KZY04_RS08550 (1789606) 1789606..1790676 - 1071 WP_032151756.1 histidinol-phosphate transaminase -
KZY04_RS08555 (1790673) 1790673..1791977 - 1305 WP_001572810.1 histidinol dehydrogenase -
KZY04_RS08560 (1791983) 1791983..1792882 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
KZY04_RS08565 (1793028) 1793028..1793078 - 51 WP_001364200.1 his operon leader peptide -
KZY04_RS08570 (1793361) 1793361..1793612 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
KZY04_RS08575 (1793609) 1793609..1793863 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
KZY04_RS08580 (1793946) 1793946..1794770 + 825 WP_000754737.1 SDR family oxidoreductase -
KZY04_RS08585 (1794816) 1794816..1795745 + 930 WP_000803360.1 LysR substrate-binding domain-containing protein -
KZY04_RS08590 (1795960) 1795960..1796022 + 63 WP_010723108.1 membrane protein YoeI -
KZY04_RS08595 (1796012) 1796012..1797370 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
KZY04_RS08600 (1797549) 1797549..1798607 + 1059 WP_219795147.1 thiosulfate utilization transporter TsuA/YeeE -
KZY04_RS08605 (1798621) 1798621..1798848 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T210996 WP_000767829.1 NZ_CP080133:1793609-1793863 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T210996 NZ_CP104659:951198-951300 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT210996 WP_001259255.1 NZ_CP080133:1793361-1793612 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT210996 NZ_CP104659:c951307-951162 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References