210992

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 714805..715498 Replicon chromosome
Accession NZ_CP080133
Organism Escherichia coli strain PK8277

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KZY04_RS03500 Protein ID WP_000415584.1
Coordinates 714805..715101 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KZY04_RS03505 Protein ID WP_000650107.1
Coordinates 715103..715498 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY04_RS03465 (709893) 709893..710207 - 315 WP_000958598.1 putative quinol monooxygenase -
KZY04_RS03470 (710238) 710238..710819 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KZY04_RS03475 (711138) 711138..711470 + 333 WP_000917684.1 DUF2645 family protein -
KZY04_RS03480 (711516) 711516..712865 - 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
KZY04_RS03485 (712862) 712862..713521 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KZY04_RS03490 (713673) 713673..714065 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KZY04_RS03495 (714118) 714118..714600 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KZY04_RS03500 (714805) 714805..715101 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KZY04_RS03505 (715103) 715103..715498 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KZY04_RS03510 (715631) 715631..717238 + 1608 WP_219795084.1 ABC transporter substrate-binding protein -
KZY04_RS03515 (717376) 717376..719634 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T210992 WP_000415584.1 NZ_CP080133:714805-715101 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T210992 NZ_CP104653:91531-91818 [Acinetobacter variabilis]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCGATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATACGAATCATTAGT
GCAAGGCAAGTGACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT210992 WP_000650107.1 NZ_CP080133:715103-715498 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT210992 NZ_CP104653:91805-92119 [Acinetobacter variabilis]
ATGAGCATGGTTAGATACTCACGCAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACCGATTGGAGCAGTGCTGTACGCC
AAAATCAATTTTACCGCCCAGTGAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGAATGAATGAAATTTTACGGGATGCTATGCTGAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References