Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 711038..711731 Replicon chromosome
Accession NZ_CP080121
Organism Escherichia coli strain PK8217

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KZO72_RS03475 Protein ID WP_000415584.1
Coordinates 711038..711334 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KZO72_RS03480 Protein ID WP_000650107.1
Coordinates 711336..711731 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZO72_RS03440 (706126) 706126..706440 - 315 WP_000958598.1 putative quinol monooxygenase -
KZO72_RS03445 (706471) 706471..707052 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KZO72_RS03450 (707371) 707371..707703 + 333 WP_000917684.1 DUF2645 family protein -
KZO72_RS03455 (707749) 707749..709098 - 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
KZO72_RS03460 (709095) 709095..709754 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KZO72_RS03465 (709906) 709906..710298 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KZO72_RS03470 (710351) 710351..710833 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KZO72_RS03475 (711038) 711038..711334 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KZO72_RS03480 (711336) 711336..711731 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KZO72_RS03485 (711864) 711864..713471 + 1608 WP_219795084.1 ABC transporter substrate-binding protein -
KZO72_RS03490 (713609) 713609..715867 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T210931 WP_000415584.1 NZ_CP080121:711038-711334 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T210931 NZ_CP104645:c4568616-4568509 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT210931 WP_000650107.1 NZ_CP080121:711336-711731 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT210931 NZ_CP104645:4568664-4568723 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References