210904

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 709063..709862 Replicon chromosome
Accession NZ_CP080120
Organism Escherichia coli strain M24

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag KZX72_RS03455 Protein ID WP_000347251.1
Coordinates 709063..709527 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag KZX72_RS03460 Protein ID WP_001296435.1
Coordinates 709527..709862 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX72_RS03425 (704064) 704064..704498 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
KZX72_RS03430 (704516) 704516..705394 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
KZX72_RS03435 (705384) 705384..706163 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
KZX72_RS03440 (706174) 706174..706647 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
KZX72_RS03445 (706670) 706670..707950 - 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
KZX72_RS03450 (708199) 708199..709008 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
KZX72_RS03455 (709063) 709063..709527 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
KZX72_RS03460 (709527) 709527..709862 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
KZX72_RS03465 (710011) 710011..711582 - 1572 WP_001273763.1 galactarate dehydratase -
KZX72_RS03470 (711957) 711957..713291 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
KZX72_RS03475 (713307) 713307..714077 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T210904 WP_000347251.1 NZ_CP080120:c709527-709063 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T210904 NZ_CP104643:c3039123-3039020 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT210904 WP_001296435.1 NZ_CP080120:c709862-709527 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT210904 NZ_CP104643:3039018-3039163 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References