Detailed information of TA system TA021088

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 3685929..3686623
• Replicon: chromosome
• Accession: NC_006155
• Organism: Yersinia pseudotuberculosis IP 32953

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: YPTB_RS16910
• Protein ID: WP_024063131.1
• Coordinates: 3686327..3686623 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q666X1
• Locus tag: YPTB_RS16905
• Protein ID: WP_002209924.1
• Coordinates: 3685929..3686327 (-)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YPTB_RS16870	3681037..3681402	+	366	WP_011192915.1	hypothetical protein	-
YPTB_RS23870	3681415..3682071	+	657	WP_011192916.1	hypothetical protein	-
YPTB_RS16885	3682253..3682453	+	201	WP_002209920.1	AlpA family transcriptional regulator	-
YPTB_RS24140	3682467..3682619	-	153	WP_002209921.1	hypothetical protein	-
YPTB_RS16895	3682612..3682938	-	327	WP_011192917.1	type II toxin-antitoxin system RelE/ParE family toxin	-
YPTB_RS16900	3683238..3685529	+	2292	WP_011192918.1	toprim domain-containing protein	-
YPTB_RS16905	3685929..3686327	-	399	WP_002209924.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
YPTB_RS16910	3686327..3686623	-	297	WP_024063131.1	type II toxin-antitoxin system MqsR family toxin	Toxin
YPTB_RS16915	3686787..3687149	-	363	WP_011192920.1	helix-turn-helix domain-containing protein	-
YPTB_RS16920	3687212..3687472	-	261	WP_002214785.1	type II toxin-antitoxin system RelE/ParE family toxin	-
YPTB_RS16930	3688070..3688255	+	186	WP_002209928.1	hypothetical protein	-
YPTB_RS16935	3688397..3689380	-	984	WP_011192921.1	tyrosine-type recombinase/integrase	-
YPTB_RS23095	3689447..3689746	-	300	WP_012413890.1	helix-turn-helix domain-containing protein	-
YPTB_RS16940	3689860..3690132	+	273	WP_011192923.1	hypothetical protein	-
YPTB_RS16945	3690129..3690341	+	213	WP_012413891.1	hypothetical protein	-
YPTB_RS16950	3690338..3690622	+	285	WP_011192924.1	hypothetical protein	-
YPTB_RS16955	3690801..3691034	-	234	WP_041175468.1	hypothetical protein	-
YPTB_RS16960	3691181..3691450	+	270	WP_011192925.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3667983..3725875	57892

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11318.17 Da
• Isoelectric Point: 7.8810

>T21088 WP_024063131.1 NC_006155:c3686623-3686327 [Yersinia pseudotuberculosis IP 32953]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLIVSFKEI

Nucleotide

• Length: 297 bp

>T21088 NC_006155:c3686623-3686327 [Yersinia pseudotuberculosis IP 32953]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGATTTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14657.17 Da
• Isoelectric Point: 8.4923

>AT21088 WP_002209924.1 NC_006155:c3686327-3685929 [Yersinia pseudotuberculosis IP 32953]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Nucleotide

• Length: 399 bp

>AT21088 NC_006155:c3686327-3685929 [Yersinia pseudotuberculosis IP 32953]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Structures

Antitoxin

• AlphaFold DB: Q666X1