Detailed information of TA system TA210878

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 1558601..1559203
• Replicon: chromosome
• Accession: NZ_CP080119
• Organism: Escherichia coli strain M45

Toxin (Protein)

• Gene name: higB
• Uniprot ID: S1P416
• Locus tag: KZX76_RS07470
• Protein ID: WP_000897302.1
• Coordinates: 1558601..1558912 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KZX76_RS07475
• Protein ID: WP_000356397.1
• Coordinates: 1558913..1559203 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZX76_RS07445 (1554515)	1554515..1555114	+	600	WP_001296610.1	glucose-1-phosphatase	-
KZX76_RS07450 (1555108)	1555108..1555980	+	873	WP_000920762.1	virulence factor BrkB family protein	-
KZX76_RS07455 (1555977)	1555977..1556414	+	438	WP_000560981.1	D-aminoacyl-tRNA deacylase	-
KZX76_RS07460 (1556459)	1556459..1557400	+	942	WP_001297068.1	fatty acid biosynthesis protein FabY	-
KZX76_RS07465 (1557464)	1557464..1558372	-	909	WP_001385591.1	alpha/beta hydrolase	-
KZX76_RS07470 (1558601)	1558601..1558912	+	312	WP_000897302.1	hypothetical protein	Toxin
KZX76_RS07475 (1558913)	1558913..1559203	+	291	WP_000356397.1	NadS family protein	Antitoxin
KZX76_RS07480 (1559562)	1559562..1559840	+	279	WP_001296612.1	hypothetical protein	-
KZX76_RS07485 (1560237)	1560237..1560455	+	219	WP_001251293.1	CopG family transcriptional regulator	-
KZX76_RS25380 (1560640)	1560640..1561380	-	741	WP_000608806.1	hypothetical protein	-
KZX76_RS07495 (1561405)	1561405..1562253	-	849	WP_001038650.1	hypothetical protein	-
KZX76_RS07500 (1562543)	1562543..1562785	+	243	WP_001068514.1	CopG family transcriptional regulator	-
KZX76_RS07505 (1562967)	1562967..1563896	-	930	WP_000027696.1	formate dehydrogenase accessory protein FdhE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12203.19 Da
• Isoelectric Point: 9.7791

>T210878 WP_000897302.1 NZ_CP080119:1558601-1558912 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Nucleotide

• Length: 312 bp

>T210878 NZ_CP104641:200452-200937 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGTGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10846.43 Da
• Isoelectric Point: 10.8907

>AT210878 WP_000356397.1 NZ_CP080119:1558913-1559203 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Nucleotide

• Length: 291 bp

>AT210878 NZ_CP104641:200177-200464 [Salmonella enterica]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Toxin

• AlphaFold DB: S1P416