Detailed information of TA system TA210844

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4815145..4815747
• Replicon: chromosome
• Accession: NZ_CP080117
• Organism: Escherichia coli strain OV24

Toxin (Protein)

• Gene name: higB
• Uniprot ID: S1P416
• Locus tag: KZX74_RS23365
• Protein ID: WP_000897302.1
• Coordinates: 4815436..4815747 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KZX74_RS23360
• Protein ID: WP_000356397.1
• Coordinates: 4815145..4815435 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZX74_RS23330 (4810452)	4810452..4811381	+	930	WP_000027696.1	formate dehydrogenase accessory protein FdhE	-
KZX74_RS23335 (4811563)	4811563..4811805	-	243	WP_001068514.1	CopG family transcriptional regulator	-
KZX74_RS23340 (4812095)	4812095..4812943	+	849	WP_001038650.1	hypothetical protein	-
KZX74_RS24410 (4812968)	4812968..4813708	+	741	WP_000608806.1	hypothetical protein	-
KZX74_RS23350 (4813893)	4813893..4814111	-	219	WP_001251293.1	CopG family transcriptional regulator	-
KZX74_RS23355 (4814508)	4814508..4814786	-	279	WP_001296612.1	hypothetical protein	-
KZX74_RS23360 (4815145)	4815145..4815435	-	291	WP_000356397.1	NadS family protein	Antitoxin
KZX74_RS23365 (4815436)	4815436..4815747	-	312	WP_000897302.1	hypothetical protein	Toxin
KZX74_RS23370 (4815976)	4815976..4816884	+	909	WP_001385591.1	alpha/beta hydrolase	-
KZX74_RS23375 (4816948)	4816948..4817889	-	942	WP_001297068.1	fatty acid biosynthesis protein FabY	-
KZX74_RS23380 (4817934)	4817934..4818371	-	438	WP_000560981.1	D-aminoacyl-tRNA deacylase	-
KZX74_RS23385 (4818368)	4818368..4819240	-	873	WP_000920762.1	virulence factor BrkB family protein	-
KZX74_RS23390 (4819234)	4819234..4819833	-	600	WP_001296610.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12203.19 Da
• Isoelectric Point: 9.7791

>T210844 WP_000897302.1 NZ_CP080117:c4815747-4815436 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Nucleotide

• Length: 312 bp

>T210844 NZ_CP104638:2492712-2492987 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCAGTTACTCACATATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACCGTGAAGATCTCCAAGGGATGTT
TGATCCTGATGGCTGAGACGGACGAAGTGAGGGAGCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATGATGTGGTGAACGGGGATTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10846.43 Da
• Isoelectric Point: 10.8907

>AT210844 WP_000356397.1 NZ_CP080117:c4815435-4815145 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Nucleotide

• Length: 291 bp

>AT210844 NZ_CP104638:c2492977-2492555 [Salmonella enterica]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGCTCCCTCAC
TTCGTCCGTCTCAGCCATCAGGATCAAACATCCCTTGGAGATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAACA
ACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: S1P416