Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2134937..2135539 Replicon chromosome
Accession NZ_CP080116
Organism Escherichia coli strain Dog168

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag KZX73_RS10535 Protein ID WP_000897302.1
Coordinates 2135228..2135539 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KZX73_RS10530 Protein ID WP_000356397.1
Coordinates 2134937..2135227 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX73_RS10500 (2130244) 2130244..2131173 + 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -
KZX73_RS10505 (2131355) 2131355..2131597 - 243 WP_001068514.1 CopG family transcriptional regulator -
KZX73_RS10510 (2131887) 2131887..2132735 + 849 WP_001038650.1 hypothetical protein -
KZX73_RS24975 (2132760) 2132760..2133500 + 741 WP_000608806.1 hypothetical protein -
KZX73_RS10520 (2133685) 2133685..2133903 - 219 WP_001251293.1 CopG family transcriptional regulator -
KZX73_RS10525 (2134300) 2134300..2134578 - 279 WP_001296612.1 hypothetical protein -
KZX73_RS10530 (2134937) 2134937..2135227 - 291 WP_000356397.1 NadS family protein Antitoxin
KZX73_RS10535 (2135228) 2135228..2135539 - 312 WP_000897302.1 hypothetical protein Toxin
KZX73_RS10540 (2135768) 2135768..2136676 + 909 WP_001385591.1 alpha/beta hydrolase -
KZX73_RS10545 (2136740) 2136740..2137681 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
KZX73_RS10550 (2137726) 2137726..2138163 - 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
KZX73_RS10555 (2138160) 2138160..2139032 - 873 WP_000920762.1 virulence factor BrkB family protein -
KZX73_RS10560 (2139026) 2139026..2139625 - 600 WP_001296610.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T210802 WP_000897302.1 NZ_CP080116:c2135539-2135228 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

>T210802 NZ_CP104621:83090-83239 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT210802 WP_000356397.1 NZ_CP080116:c2135227-2134937 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT210802 NZ_CP104621:c83045-82986 [Escherichia coli]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References