Detailed information of TA system TA210789

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3755449..3756106
• Replicon: chromosome
• Accession: NZ_CP080107
• Organism: Enterobacter asburiae strain WW-19C

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A808IF03
• Locus tag: KZX48_RS18170
• Protein ID: WP_033146338.1
• Coordinates: 3755449..3755748 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KZX48_RS18175
• Protein ID: WP_094935697.1
• Coordinates: 3755759..3756106 (+)
• Length: 116 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZX48_RS18155 (KZX48_18145)	3750715..3751822	+	1108	Protein_3554	TolC family protein	-
KZX48_RS18160 (KZX48_18150)	3751819..3754017	+	2199	WP_112778387.1	type I secretion system permease/ATPase	-
KZX48_RS18165 (KZX48_18155)	3754028..3755197	+	1170	WP_086374946.1	HlyD family efflux transporter periplasmic adaptor subunit	-
KZX48_RS18170 (KZX48_18160)	3755449..3755748	+	300	WP_033146338.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KZX48_RS18175 (KZX48_18165)	3755759..3756106	+	348	WP_094935697.1	HigA family addiction module antitoxin	Antitoxin
KZX48_RS18180 (KZX48_18170)	3756151..3756576	+	426	WP_033146340.1	nucleoside triphosphatase NudI	-
KZX48_RS18185 (KZX48_18175)	3756548..3757279	-	732	WP_094935696.1	helix-turn-helix transcriptional regulator	-
KZX48_RS18190 (KZX48_18180)	3757377..3757796	+	420	WP_039263434.1	nuclear transport factor 2 family protein	-
KZX48_RS18195 (KZX48_18185)	3757799..3758317	-	519	WP_094935695.1	hypothetical protein	-
KZX48_RS18200 (KZX48_18190)	3758402..3759583	-	1182	WP_094935694.1	PLP-dependent aminotransferase family protein	-
KZX48_RS18205 (KZX48_18195)	3759604..3760491	-	888	WP_096151492.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-95)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (8-86)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11691.32 Da
• Isoelectric Point: 10.0346

>T210789 WP_033146338.1 NZ_CP080107:3755449-3755748 [Enterobacter asburiae]
MISYFRDQWLEDFFLYGRSSNVIPANLETALARKLDIIRAATSHRDLRSPPGNMYEALNPPLKGYSSIRVNRQYRLVFRW
TEGKAEDLYLSPHKYTQHK

Nucleotide

• Length: 300 bp

>T210789 NZ_CP104618:c2402399-2402223 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 116 a.a.
• Molecular weight: 13084.05 Da
• Isoelectric Point: 7.0134

>AT210789 WP_094935697.1 NZ_CP080107:3755759-3756106 [Enterobacter asburiae]
MTLQQALRKPTTPGDVMQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSNPRTQEELSRIKTVADVMAKRKSGQPDVA

Nucleotide

• Length: 348 bp

>AT210789 NZ_CP104618:c2402177-2401761 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATAGTTTAA

Structures

Toxin

• AlphaFold DB: A0A808IF03