Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 232681..233274 Replicon chromosome
Accession NZ_CP080095
Organism Paraburkholderia edwinii strain Pe01

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag KZJ38_RS01005 Protein ID WP_219798386.1
Coordinates 232996..233274 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KZJ38_RS01000 Protein ID WP_219798385.1
Coordinates 232681..232983 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZJ38_RS00990 (KZJ38_00990) 230200..232353 + 2154 WP_246641597.1 exodeoxyribonuclease V subunit alpha -
KZJ38_RS00995 (KZJ38_00995) 232376..232672 + 297 WP_219798384.1 hypothetical protein -
KZJ38_RS01000 (KZJ38_01000) 232681..232983 - 303 WP_219798385.1 HigA family addiction module antitoxin Antitoxin
KZJ38_RS01005 (KZJ38_01005) 232996..233274 - 279 WP_219798386.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZJ38_RS01010 (KZJ38_01010) 233644..233844 + 201 WP_219798387.1 KTSC domain-containing protein -
KZJ38_RS01015 (KZJ38_01015) 233878..234318 - 441 WP_219798388.1 zinc-finger-containing protein -
KZJ38_RS01020 (KZJ38_01020) 234425..235021 - 597 WP_219798389.1 hypothetical protein -
KZJ38_RS01025 (KZJ38_01025) 235134..235244 + 111 Protein_201 recombinase family protein -
KZJ38_RS01030 (KZJ38_01030) 235285..236841 - 1557 WP_219798390.1 ATP-binding protein -
KZJ38_RS01035 (KZJ38_01035) 236846..237415 - 570 WP_219798391.1 hypothetical protein -
KZJ38_RS01040 (KZJ38_01040) 237420..237605 - 186 WP_219798392.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10721.22 Da        Isoelectric Point: 8.5350

>T210748 WP_219798386.1 NZ_CP080095:c233274-232996 [Paraburkholderia edwinii]
MIESFRCKDTEALYKGESPKRFRSIESVAVRKLQMLEAAHELKDLRAPPGNRLEPLHGNRTNRHSIRINGQWRICFVWTS
DGATEVEIIDYH

Download         Length: 279 bp

>T210748 NZ_CP104606:c14266-13916 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11354.03 Da        Isoelectric Point: 6.4719

>AT210748 WP_219798385.1 NZ_CP080095:c232983-232681 [Paraburkholderia edwinii]
MVKNGMRAVHPGEVLREEFLVPLEMSVNALSLALSVPSTRLHEIVNERRGITADTAYRLARYFDTTPEFWLNLQIAYDLK
TLPTRAEIDRKVEPRESAGA

Download         Length: 303 bp

>AT210748 NZ_CP104606:c13911-13609 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References