Detailed information of TA system TA210725

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2444734..2444959
• Replicon: chromosome
• Accession: NZ_CP080091
• Organism: Salmonella enterica strain SLR1_8245

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: KZY40_RS11840
• Protein ID: WP_000813254.1
• Coordinates: 2444734..2444889 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2444901..2444959 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZY40_RS11805	2439841..2440122	-	282	WP_000445513.1	phage holin family protein	-
KZY40_RS11810	2440112..2440300	-	189	WP_001688615.1	putative holin	-
KZY40_RS11815	2440294..2440617	-	324	Protein_2325	tellurite/colicin resistance protein	-
KZY40_RS11820	2442788..2443324	-	537	WP_000640113.1	DUF1133 family protein	-
KZY40_RS11825	2443321..2443611	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
KZY40_RS11830	2443611..2444210	-	600	WP_000940751.1	DUF1367 family protein	-
KZY40_RS11835	2444273..2444443	-	171	WP_000734094.1	hypothetical protein	-
KZY40_RS11840	2444734..2444889	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2444901..2444959	+	59	-	-	Antitoxin
KZY40_RS11845	2445316..2446248	+	933	WP_000556390.1	hypothetical protein	-
KZY40_RS11850	2446245..2446799	+	555	WP_001033796.1	hypothetical protein	-
KZY40_RS11855	2446961..2447290	-	330	WP_001676916.1	DUF977 family protein	-
KZY40_RS23675	2447334..2447381	-	48	Protein_2334	hypothetical protein	-
KZY40_RS11865	2447563..2448030	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
KZY40_RS11870	2448415..2448570	+	156	WP_085981757.1	DUF1391 family protein	-
KZY40_RS11875	2448678..2449199	-	522	WP_000004762.1	super-infection exclusion protein B	-
KZY40_RS11880	2449637..2449858	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2439299..2451170	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T210725 WP_000813254.1 NZ_CP080091:c2444889-2444734 [Salmonella enterica]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T210725 NZ_CP104598:c4351573-4351046 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCATTCAATACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCAGTAGGTATTCACGGTCTTTTTGTAG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCGTTGGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT210725 NZ_CP080091:2444901-2444959 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin