Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2261903..2262596 Replicon chromosome
Accession NZ_CP080085
Organism Escherichia coli strain 19SZHZ869Rt

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KZO18_RS11075 Protein ID WP_000415584.1
Coordinates 2262300..2262596 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KZO18_RS11070 Protein ID WP_000650107.1
Coordinates 2261903..2262298 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZO18_RS11060 (2257767) 2257767..2260025 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
KZO18_RS11065 (2260163) 2260163..2261770 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KZO18_RS11070 (2261903) 2261903..2262298 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KZO18_RS11075 (2262300) 2262300..2262596 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KZO18_RS11080 (2262801) 2262801..2263283 - 483 WP_000183505.1 GyrI-like domain-containing protein -
KZO18_RS11085 (2263336) 2263336..2263728 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KZO18_RS11090 (2263880) 2263880..2264539 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KZO18_RS11095 (2264536) 2264536..2265885 + 1350 WP_249768865.1 quorum sensing histidine kinase QseC -
KZO18_RS11100 (2265931) 2265931..2266263 - 333 WP_000917684.1 DUF2645 family protein -
KZO18_RS11105 (2266582) 2266582..2267163 + 582 WP_087905501.1 NADPH:quinone oxidoreductase MdaB -
KZO18_RS11110 (2267194) 2267194..2267508 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T210705 WP_000415584.1 NZ_CP080085:c2262596-2262300 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T210705 NZ_CP104596:34673-35089 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT210705 WP_000650107.1 NZ_CP080085:c2262298-2261903 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT210705 NZ_CP104596:34446-34676 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References