Detailed information of TA system TA210688

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 79520..79946
• Replicon: plasmid p886Rt_hybrid
• Accession: NZ_CP080082
• Organism: Escherichia coli strain 19SZHZ886Rt

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: KZO17_RS23865
• Protein ID: WP_001372321.1
• Coordinates: 79520..79645 (-)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	79722..79946 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZO17_RS23820 (74568)	74568..74795	-	228	WP_001254386.1	conjugal transfer relaxosome protein TraY	-
KZO17_RS23825 (74890)	74890..75576	-	687	WP_015059009.1	PAS domain-containing protein	-
KZO17_RS23830 (75767)	75767..76150	-	384	WP_000124981.1	conjugal transfer relaxosome DNA-binding protein TraM	-
KZO17_RS23835 (76427)	76427..77074	+	648	WP_148726238.1	transglycosylase SLT domain-containing protein	-
KZO17_RS23840 (77371)	77371..78192	-	822	WP_033804334.1	DUF932 domain-containing protein	-
KZO17_RS23845 (78311)	78311..78598	-	288	WP_000107535.1	hypothetical protein	-
KZO17_RS23850 (78623)	78623..78829	-	207	WP_033804333.1	hypothetical protein	-
KZO17_RS23855 (78899)	78899..79072	+	174	Protein_81	hypothetical protein	-
KZO17_RS23860 (79070)	79070..79300	-	231	WP_071845785.1	hypothetical protein	-
KZO17_RS23865 (79520)	79520..79645	-	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
KZO17_RS23870 (79587)	79587..79736	-	150	Protein_84	plasmid maintenance protein Mok	-
- (79722)	79722..79946	-	225	NuclAT_0	-	Antitoxin
- (79722)	79722..79946	-	225	NuclAT_0	-	Antitoxin
- (79722)	79722..79946	-	225	NuclAT_0	-	Antitoxin
- (79722)	79722..79946	-	225	NuclAT_0	-	Antitoxin
KZO17_RS23875 (79758)	79758..79946	+	189	WP_063073474.1	hypothetical protein	-
KZO17_RS23880 (79915)	79915..80677	-	763	Protein_86	plasmid SOS inhibition protein A	-
KZO17_RS23885 (80674)	80674..81108	-	435	WP_000845907.1	conjugation system SOS inhibitor PsiB	-
KZO17_RS23890 (81163)	81163..83121	-	1959	WP_063072993.1	ParB/RepB/Spo0J family partition protein	-
KZO17_RS23895 (83186)	83186..83419	-	234	WP_000006030.1	DUF905 family protein	-
KZO17_RS23900 (83481)	83481..83933	-	453	WP_000290842.1	single-stranded DNA-binding protein	-
KZO17_RS23905 (83959)	83959..84165	-	207	WP_000275853.1	hypothetical protein	-
KZO17_RS23910 (84406)	84406..84681	-	276	WP_071780182.1	hypothetical protein	-
KZO17_RS23915 (84576)	84576..84806	-	231	WP_021526513.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaTEM-1B	-	1..110148	110148

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T210688 WP_001372321.1 NZ_CP080082:c79645-79520 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T210688 NZ_CP104595:1065851-1066186 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 225 bp

>AT210688 NZ_CP080082:c79946-79722 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGACAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin