Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1780215..1780717 Replicon chromosome
Accession NZ_CP080075
Organism Escherichia coli strain 19SZHZ663Rt

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KZO16_RS08415 Protein ID WP_001471733.1
Coordinates 1780463..1780717 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag KZO16_RS08410 Protein ID WP_001259255.1
Coordinates 1780215..1780466 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZO16_RS08385 (1775393) 1775393..1776460 - 1068 WP_001374028.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
KZO16_RS08390 (1776460) 1776460..1777530 - 1071 WP_001374029.1 histidinol-phosphate transaminase -
KZO16_RS08395 (1777527) 1777527..1778831 - 1305 WP_001748534.1 histidinol dehydrogenase -
KZO16_RS08400 (1778837) 1778837..1779736 - 900 WP_001374031.1 ATP phosphoribosyltransferase -
KZO16_RS08405 (1779882) 1779882..1779932 - 51 WP_001364200.1 his operon leader peptide -
KZO16_RS08410 (1780215) 1780215..1780466 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
KZO16_RS08415 (1780463) 1780463..1780717 + 255 WP_001471733.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
KZO16_RS08420 (1780800) 1780800..1781624 + 825 WP_000754737.1 SDR family oxidoreductase -
KZO16_RS08425 (1781670) 1781670..1782599 + 930 WP_001374016.1 LysR substrate-binding domain-containing protein -
KZO16_RS08430 (1782814) 1782814..1782876 + 63 WP_010723108.1 membrane protein YoeI -
KZO16_RS08435 (1782866) 1782866..1784224 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10195.64 Da        Isoelectric Point: 8.0353

>T210642 WP_001471733.1 NZ_CP080075:1780463-1780717 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDIRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T210642 NZ_CP104583:c441626-441345 [Pseudomonas sp. GD03721]
GTGAAGCTGGCCTGGACGCGCCTTGCGCTGAACGACCGCCAAGCCATCCGCAGTTATATCGCTCAGGACAATCCCATTGC
CGCCCTGGCGCTGGATGAGTTATTCGCAGAAAAGGCCGGCCGTCTGGCCGATCACCCCGGCCTGGGGCGACCAGGCCGGG
TGAACGGTACACGCGAACTGGTTGTTCATCAGCATTACCTGATGATCTACGACCTGGCCAATGATCAGGTACGGATACTG
CGCGTGCTGCATACAGCGCGTCAGTGGCCCAGTGCGGACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT210642 WP_001259255.1 NZ_CP080075:1780215-1780466 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT210642 NZ_CP104583:c441913-441623 [Pseudomonas sp. GD03721]
ATGAGTGAAGCCACCTTTACCTTTCGCGTGGACGACGCCCTGAAAAGCGAATTTGCCCAGGCTGCCAAAGCCCGCGACCG
CACTGGCGCGCAGTTGCTGCGCGACTTCATGCGTGATTTCGTCCGACAGCAGCAGGAGGCCGCCGAGCACGATGTCTGGC
TGCGCCGCCAGGTACAGATGGGGCTGGATTCGGCCAATGCTGGTGAGTTGCTCAGTGGCGAAGAGGTCGAAGCCGAAGCC
GCCGCATGGCGTGCTGAAATGCGCCGCAAGCTGGACAGCGCCGCGTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References