Detailed information of TA system TA021063

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 406772..407399
• Replicon: chromosome
• Accession: NC_005956
• Organism: Bartonella henselae str. Houston-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0H3M2H0
• Locus tag: AYT27_RS01770
• Protein ID: WP_011180277.1
• Coordinates: 406772..407086 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: AYT27_RS01775
• Protein ID: WP_011180278.1
• Coordinates: 407103..407399 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AYT27_RS01750	402399..403955	-	1557	WP_011180273.1	phage portal protein	-
AYT27_RS01755	403955..404203	-	249	WP_011180274.1	hypothetical protein	-
AYT27_RS01760	404207..406135	-	1929	WP_011180275.1	phage terminase large subunit family protein	-
AYT27_RS01765	406128..406709	-	582	WP_011180276.1	hypothetical protein	-
AYT27_RS01770	406772..407086	+	315	WP_011180277.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AYT27_RS01775	407103..407399	+	297	WP_011180278.1	HigA family addiction module antidote protein	Antitoxin
AYT27_RS01780	407809..408072	+	264	WP_011180280.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
AYT27_RS01785	408059..408340	+	282	WP_011180281.1	type II toxin-antitoxin system YafQ family toxin	-
AYT27_RS01790	408383..408661	-	279	WP_011180242.1	hypothetical protein	-
AYT27_RS01795	408658..409416	-	759	WP_011180282.1	phage antirepressor Ant	-
AYT27_RS01800	409476..409991	-	516	WP_011180283.1	phage antirepressor Ant	-
AYT27_RS01805	410284..410847	-	564	Protein_331	antA/AntB antirepressor family protein	-
AYT27_RS01810	410879..411421	-	543	WP_011180285.1	phage antirepressor Ant	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	363045..433232	70187

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (15-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-67)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12135.97 Da
• Isoelectric Point: 9.0878

>T21063 WP_011180277.1 NC_005956:406772-407086 [Bartonella henselae str. Houston-1]
MIHKRTNEGDLVIESFADKRCKDLLEGNPPKGFPTTLVRIVQRKLFMLDKAVDLKDLRSPPGNRLEALKGERKGQYSIRI
NDQFRICFEWRSNGAYEVEIVDYH

Nucleotide

• Length: 315 bp

>T21063 NC_005956:406772-407086 [Bartonella henselae str. Houston-1]
ATGATACATAAAAGAACGAATGAAGGTGACTTGGTAATTGAATCTTTTGCGGATAAGCGGTGTAAAGATCTTTTAGAAGG
CAATCCACCTAAAGGTTTTCCCACAACTCTCGTGCGTATAGTCCAACGAAAATTATTTATGCTGGATAAAGCAGTTGATC
TCAAAGATTTACGCAGTCCTCCGGGTAATCGTTTAGAGGCATTGAAAGGAGAGCGTAAAGGTCAATATTCTATTCGTATT
AATGACCAGTTTCGCATTTGTTTTGAGTGGCGTTCTAATGGTGCCTATGAAGTTGAAATCGTCGATTATCATTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11262.91 Da
• Isoelectric Point: 5.8690

>AT21063 WP_011180278.1 NC_005956:407103-407399 [Bartonella henselae str. Houston-1]
MKNYIAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIVAENSRITPDTALRLASFFDTTAEFWLNMQAAYDVSVL
QAEKADEFSKISKFECRV

Nucleotide

• Length: 297 bp

>AT21063 NC_005956:407103-407399 [Bartonella henselae str. Houston-1]
ATGAAAAATTATATTGCTATTCATCCCGGAGAAATTTTACGGGAAGAATATTTAAAAGAATATGCTCTCTCTGCTTATGC
TCTTGCCAAAGCCTTGAATGTTCCACGCACTCGGATAGAACGGATTGTAGCAGAAAATAGTCGGATAACTCCTGATACAG
CACTACGATTAGCCTCTTTTTTTGATACAACAGCTGAATTCTGGCTCAACATGCAAGCTGCTTACGATGTCAGTGTCTTA
CAAGCTGAAAAAGCAGATGAATTTTCCAAAATTAGTAAATTTGAATGTAGAGTTTAA

Structures

Toxin

• AlphaFold DB: A0A0H3M2H0