Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1815905..1816407 | Replicon | chromosome |
| Accession | NZ_CP080070 | ||
| Organism | Escherichia coli strain 19SZHZ713Rt | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | KZO15_RS08565 | Protein ID | WP_000767829.1 |
| Coordinates | 1816153..1816407 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | KZO15_RS08560 | Protein ID | WP_001259255.1 |
| Coordinates | 1815905..1816156 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZO15_RS08535 (1811082) | 1811082..1812149 | - | 1068 | WP_000080081.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| KZO15_RS08540 (1812149) | 1812149..1813219 | - | 1071 | WP_032259172.1 | histidinol-phosphate transaminase | - |
| KZO15_RS08545 (1813216) | 1813216..1814520 | - | 1305 | WP_089551543.1 | histidinol dehydrogenase | - |
| KZO15_RS08550 (1814526) | 1814526..1815425 | - | 900 | WP_000131756.1 | ATP phosphoribosyltransferase | - |
| KZO15_RS08555 (1815571) | 1815571..1815621 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| KZO15_RS08560 (1815905) | 1815905..1816156 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| KZO15_RS08565 (1816153) | 1816153..1816407 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| KZO15_RS08570 (1816490) | 1816490..1817314 | + | 825 | WP_000754758.1 | SDR family oxidoreductase | - |
| KZO15_RS08575 (1817360) | 1817360..1818289 | + | 930 | WP_000803370.1 | LysR substrate-binding domain-containing protein | - |
| KZO15_RS08580 (1818504) | 1818504..1818566 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| KZO15_RS08585 (1818556) | 1818556..1819914 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| KZO15_RS08590 (1820093) | 1820093..1821151 | + | 1059 | WP_024195240.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| KZO15_RS08595 (1821165) | 1821165..1821392 | + | 228 | WP_000985270.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T210622 WP_000767829.1 NZ_CP080070:1816153-1816407 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T210622 NZ_CP104580:2091098-2091349 [Stutzerimonas stutzeri]
ATGCGCACTATCAGCTATACCGAAGCCCGGCAGAACCTGTCGGCCACCATGGTGCAGACCGTCGAGGATCGCGTGCCTAC
CCTCATTACCCGCCAGAACGGCGAGGCGTGCGTGCTGATGTCGCTGGAGGAGTACAACGCGCTGGAGGAAACGGCTTACC
TGCTGCGCTCGCCGGCCAACGCGCGCCGCCTGATGGATTCGATTGACAGCCTCAAGCGTGGCCAGGGTGTCGAGCGGGAT
ATCGCCGAGTGA
ATGCGCACTATCAGCTATACCGAAGCCCGGCAGAACCTGTCGGCCACCATGGTGCAGACCGTCGAGGATCGCGTGCCTAC
CCTCATTACCCGCCAGAACGGCGAGGCGTGCGTGCTGATGTCGCTGGAGGAGTACAACGCGCTGGAGGAAACGGCTTACC
TGCTGCGCTCGCCGGCCAACGCGCGCCGCCTGATGGATTCGATTGACAGCCTCAAGCGTGGCCAGGGTGTCGAGCGGGAT
ATCGCCGAGTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT210622 WP_001259255.1 NZ_CP080070:1815905-1816156 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT210622 NZ_CP104580:2091346-2091600 [Stutzerimonas stutzeri]
GTGAAGCTGATCTGGTCTGAGCAAGCCTGGGACGATTATCTGTACTGGCAAGAGGCGGATAAGCGTATGGTCAAGAAGCT
CAACGAGCTGATCAAGGAGACCCGCCGCACCCCTTTCGAGGGCAAGGGCAAGCCGGAGCCGCTTCGCCACAACCTGGCGG
GCTTCTGGTCGAGGCGGATCACCGCCGAGCACCGGTTTGTGTATTCGGTGACGGACGAGGCGCTGCTGATTGCCGCCTGC
CGTTATCACTATTGA
GTGAAGCTGATCTGGTCTGAGCAAGCCTGGGACGATTATCTGTACTGGCAAGAGGCGGATAAGCGTATGGTCAAGAAGCT
CAACGAGCTGATCAAGGAGACCCGCCGCACCCCTTTCGAGGGCAAGGGCAAGCCGGAGCCGCTTCGCCACAACCTGGCGG
GCTTCTGGTCGAGGCGGATCACCGCCGAGCACCGGTTTGTGTATTCGGTGACGGACGAGGCGCTGCTGATTGCCGCCTGC
CGTTATCACTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|