Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 766902..767595 Replicon chromosome
Accession NZ_CP080070
Organism Escherichia coli strain 19SZHZ713Rt

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KZO15_RS03715 Protein ID WP_000415584.1
Coordinates 766902..767198 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KZO15_RS03720 Protein ID WP_000650107.1
Coordinates 767200..767595 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZO15_RS03680 (761990) 761990..762304 - 315 WP_000958598.1 putative quinol monooxygenase -
KZO15_RS03685 (762335) 762335..762916 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KZO15_RS03690 (763235) 763235..763567 + 333 WP_157700691.1 DUF2645 family protein -
KZO15_RS03695 (763613) 763613..764962 - 1350 WP_000673354.1 quorum sensing histidine kinase QseC -
KZO15_RS03700 (764959) 764959..765618 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
KZO15_RS03705 (765770) 765770..766162 + 393 WP_075826731.1 OB fold stress tolerance protein YgiW -
KZO15_RS03710 (766215) 766215..766697 + 483 WP_000183494.1 GyrI-like domain-containing protein -
KZO15_RS03715 (766902) 766902..767198 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KZO15_RS03720 (767200) 767200..767595 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KZO15_RS03725 (767728) 767728..769335 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KZO15_RS03730 (769473) 769473..771731 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T210619 WP_000415584.1 NZ_CP080070:766902-767198 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T210619 NZ_CP104579:3785635-3785916 [Pseudomonas oleovorans]
GTGAAACTAGCCTGGACGCGTCTTGCGCTGAACGACCGCCAAGCCATCCGCAGTTATATCGCTCAGGACAATCCCATTGC
CACCCTGGCGCTGGATGAATTGTTCACGGAGAAGGCCAGTCGCCTGGCCGATCATCCCGGCTTGGGGCGACCAGGCCGGG
TAAGCGGCACTCGCGAACTGGTTGTGCATCAGCACGATCTGATGATCTACGACCTGGTCAATGACCAAGTACGGATACTC
CGCGTGTTGCATACGGCCCGCCAGTGGCCAAGTGCAGACTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT210619 WP_000650107.1 NZ_CP080070:767200-767595 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT210619 NZ_CP104579:3785348-3785638 [Pseudomonas oleovorans]
ATGAGTGAAGCCACCTTTACCTTTCGCGTAGACGACGCCCTGAAAAGCGAATTTGCCCAGGCAGCCAAGGCCCGCGACCG
TACCGGCGCGCAGTTGCTGCGCGACTTCATGCGCGACTTCGTCCGGCAGCAGCAAGAGGCCGCCGAGCACGATGTCTGGC
TGCGCCGCCAGGTACAGATGGGGCTGGATTCGGCCAATGCCGGTGAGTTGCTCAGCAGCGAAGAGGTCGAAGCCGAAGCC
GCCGCATGGCGCGCTGAAATGCGCCGCAAGCTGGACAGCGCCGCGTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References