Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1826289..1826791 | Replicon | chromosome |
| Accession | NZ_CP080066 | ||
| Organism | Escherichia coli strain 19SZHZ803Rt | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | KZO14_RS08745 | Protein ID | WP_000767829.1 |
| Coordinates | 1826537..1826791 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | KZO14_RS08740 | Protein ID | WP_001259255.1 |
| Coordinates | 1826289..1826540 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZO14_RS08715 (1821467) | 1821467..1822534 | - | 1068 | WP_000080085.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| KZO14_RS08720 (1822534) | 1822534..1823604 | - | 1071 | WP_000108967.1 | histidinol-phosphate transaminase | - |
| KZO14_RS08725 (1823601) | 1823601..1824905 | - | 1305 | WP_001593467.1 | histidinol dehydrogenase | - |
| KZO14_RS08730 (1824911) | 1824911..1825810 | - | 900 | WP_094304651.1 | ATP phosphoribosyltransferase | - |
| KZO14_RS08735 (1825956) | 1825956..1826006 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| KZO14_RS08740 (1826289) | 1826289..1826540 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| KZO14_RS08745 (1826537) | 1826537..1826791 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| KZO14_RS08750 (1826874) | 1826874..1827698 | + | 825 | WP_000754763.1 | SDR family oxidoreductase | - |
| KZO14_RS08755 (1827744) | 1827744..1828673 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| KZO14_RS08760 (1828888) | 1828888..1828950 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| KZO14_RS08765 (1828940) | 1828940..1830298 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| KZO14_RS08770 (1830477) | 1830477..1831535 | + | 1059 | WP_023568741.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| KZO14_RS08775 (1831549) | 1831549..1831776 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T210598 WP_000767829.1 NZ_CP080066:1826537-1826791 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T210598 NZ_CP104557:c5112878-5112579 [Pseudomonas promysalinigenes]
ATGAAAGAACAGTTTTATGATTACGACCCAGCCGAAGCGCTTACCGATGCAGAGTCCATCGCCATATTCATGGAGGATGC
GTTTGAGACGGGTGACGCGGCGTACATTGCGCAGGCCCTCGGTGTAGTGGCCCGCGCTAAGGGTATGACCACTATTGCCA
CTGAGGCGGGTGTTTCCCGGGAGCATCTGTATCGGTCGTTCTCGGCGAAAGGTAACCCTACGCTCAAGACGATGTTGGCT
GTGATGCGGGCGGTTGGTCTGGACCTGACCTCCCGCAGACACAGCAAACCGGCGCAGTGA
ATGAAAGAACAGTTTTATGATTACGACCCAGCCGAAGCGCTTACCGATGCAGAGTCCATCGCCATATTCATGGAGGATGC
GTTTGAGACGGGTGACGCGGCGTACATTGCGCAGGCCCTCGGTGTAGTGGCCCGCGCTAAGGGTATGACCACTATTGCCA
CTGAGGCGGGTGTTTCCCGGGAGCATCTGTATCGGTCGTTCTCGGCGAAAGGTAACCCTACGCTCAAGACGATGTTGGCT
GTGATGCGGGCGGTTGGTCTGGACCTGACCTCCCGCAGACACAGCAAACCGGCGCAGTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT210598 WP_001259255.1 NZ_CP080066:1826289-1826540 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT210598 NZ_CP104557:c5113177-5112875 [Pseudomonas promysalinigenes]
ATGAAGAGTATCAAGCAGACAGCCACCTACAGGAATTGGGAGCGCAAGCTACGGGACAAGCAGGCTAGGGCAATAATTGC
TGCACGCGTTTTTCGCCTGGCGCATGGTTTGCTTGGTGATGTCCAGCCAGTGGGTCAAGGTATCAGCGAACTGCGTATCC
ATCACGGCCCCGGTTACCGTATCTATTATCAGCAACGCGGTAATCAGTTGGTACTGTTGTTATGTGGTGGGGACAAGAGC
AGCCAGTCGCGAGATATCGAGACAGCGAAATCACTGGCCAGCCAGTGGAGTGATGATGAATGA
ATGAAGAGTATCAAGCAGACAGCCACCTACAGGAATTGGGAGCGCAAGCTACGGGACAAGCAGGCTAGGGCAATAATTGC
TGCACGCGTTTTTCGCCTGGCGCATGGTTTGCTTGGTGATGTCCAGCCAGTGGGTCAAGGTATCAGCGAACTGCGTATCC
ATCACGGCCCCGGTTACCGTATCTATTATCAGCAACGCGGTAATCAGTTGGTACTGTTGTTATGTGGTGGGGACAAGAGC
AGCCAGTCGCGAGATATCGAGACAGCGAAATCACTGGCCAGCCAGTGGAGTGATGATGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|