Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3214943..3215451 Replicon chromosome
Accession NZ_CP080029
Organism Streptomyces anulatus strain VUW1

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KZO11_RS14070 Protein ID WP_219610408.1
Coordinates 3215191..3215451 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1C4HSG8
Locus tag KZO11_RS14065 Protein ID WP_050358889.1
Coordinates 3214943..3215194 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZO11_RS14050 (KZO11_14045) 3210676..3212493 - 1818 WP_219610405.1 ABC-F family ATP-binding cassette domain-containing protein -
KZO11_RS14055 (KZO11_14050) 3212635..3213762 + 1128 WP_219610406.1 hypothetical protein -
KZO11_RS14060 (KZO11_14055) 3213759..3214841 + 1083 WP_219610407.1 hypothetical protein -
KZO11_RS14065 (KZO11_14060) 3214943..3215194 + 252 WP_050358889.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KZO11_RS14070 (KZO11_14065) 3215191..3215451 + 261 WP_219610408.1 Txe/YoeB family addiction module toxin Toxin
KZO11_RS14075 (KZO11_14070) 3215439..3216800 - 1362 WP_219610409.1 acyltransferase -
KZO11_RS14080 (KZO11_14075) 3216890..3217789 - 900 WP_219614137.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
KZO11_RS14085 (KZO11_14080) 3217795..3218667 - 873 WP_219610410.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
KZO11_RS14090 (KZO11_14085) 3218664..3219986 - 1323 WP_219610411.1 resuscitation-promoting factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10480.85 Da        Isoelectric Point: 9.7521

>T210563 WP_219610408.1 NZ_CP080029:3215191-3215451 [Streptomyces anulatus]
VKFVWDQSSWDDYVWWRNQDRKILKRINTLLQDIARNGNEGMGKPEPLKHGFQGYWSRRITDEHRLIYKVVDDEVRVAAC
RYHYGR

Download         Length: 261 bp

>T210563 NZ_CP104540:c97463-97314 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9327.42 Da        Isoelectric Point: 4.5447

>AT210563 WP_050358889.1 NZ_CP080029:3214943-3215194 [Streptomyces anulatus]
MRTMTYTESRAKYAETLSAVVDDREEVVVTRAGHEPVVIVALDEYESLKETAYQLRSPENARRLLASIDRLENGGGTVRE
LAE

Download         Length: 252 bp

>AT210563 NZ_CP104540:97507-97568 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C4HSG8

References