Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe(toxin)
Location 1023159..1023670 Replicon chromosome
Accession NZ_CP080013
Organism Macrococcus caseolyticus strain 19Msa1047

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KYI12_RS05165 Protein ID WP_219494761.1
Coordinates 1023410..1023670 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KYI12_RS05160 Protein ID WP_086042489.1
Coordinates 1023159..1023410 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYI12_RS05125 (KYI12_05120) 1018812..1019315 - 504 WP_219494756.1 peptide-methionine (S)-S-oxide reductase MsrA -
KYI12_RS05130 (KYI12_05125) 1019437..1020378 + 942 WP_219494757.1 LCP family protein -
KYI12_RS05135 (KYI12_05130) 1020409..1020597 - 189 WP_041635987.1 2-hydroxymuconate tautomerase -
KYI12_RS05140 (KYI12_05135) 1020646..1021650 - 1005 WP_219494758.1 cation diffusion facilitator family transporter -
KYI12_RS05145 (KYI12_05140) 1021811..1022197 + 387 WP_219494759.1 sporulation protein -
KYI12_RS05150 (KYI12_05145) 1022376..1022516 - 141 WP_186309442.1 hypothetical protein -
KYI12_RS05155 (KYI12_05150) 1022609..1023073 + 465 WP_219494760.1 NUDIX domain-containing protein -
KYI12_RS05160 (KYI12_05155) 1023159..1023410 + 252 WP_086042489.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KYI12_RS05165 (KYI12_05160) 1023410..1023670 + 261 WP_219494761.1 Txe/YoeB family addiction module toxin Toxin
KYI12_RS05170 (KYI12_05165) 1023671..1024120 - 450 WP_219494762.1 GNAT family N-acetyltransferase -
KYI12_RS05175 (KYI12_05170) 1024203..1024943 + 741 WP_219494763.1 hypothetical protein -
KYI12_RS05180 (KYI12_05175) 1024953..1025765 + 813 WP_219494764.1 phosphotransferase -
KYI12_RS05185 (KYI12_05180) 1025875..1026360 + 486 WP_219494765.1 NUDIX domain-containing protein -
KYI12_RS05190 (KYI12_05185) 1026366..1027124 + 759 WP_219494766.1 hypothetical protein -
KYI12_RS05195 (KYI12_05190) 1027152..1027424 - 273 WP_219494767.1 Txe/YoeB family addiction module toxin -
KYI12_RS05200 (KYI12_05195) 1027417..1027674 - 258 WP_096076547.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-59)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10307.01 Da        Isoelectric Point: 10.3592

>T210559 WP_219494761.1 NZ_CP080013:1023410-1023670 [Macrococcus caseolyticus]
MYKVVMKSSVKKDLKKIKNTHLETNFLKIIKQLKENPYNNNHSFEKLIPPIKGFYSRRLNVQHRVVYTVNDEDKIVTIYS
AYGRYE

Download         Length: 261 bp

>T210559 NZ_CP104540:52062-52478 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9590.65 Da        Isoelectric Point: 4.0373

>AT210559 WP_086042489.1 NZ_CP080013:1023159-1023410 [Macrococcus caseolyticus]
MNTYTPTSARKDFFNIIKSVNEDSKEIYIAPTKIGEKGAVLVGEDDWNAIQETLFLLEKGIAYQIEQRKDEEEIDFDSTW
DNI

Download         Length: 252 bp

>AT210559 NZ_CP104540:51835-52065 [Escherichia coli]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References