210550

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5291651..5292246 Replicon chromosome
Accession NZ_CP080007
Organism Pseudomonas aeruginosa strain S-1

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag KXE03_RS24320 Protein ID WP_003113526.1
Coordinates 5291968..5292246 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KXE03_RS24315 Protein ID WP_003113527.1
Coordinates 5291651..5291956 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXE03_RS24280 (KXE03_24270) 5286790..5287638 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
KXE03_RS24290 (KXE03_24280) 5287805..5288746 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
KXE03_RS24295 (KXE03_24285) 5288863..5289477 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
KXE03_RS24300 (KXE03_24290) 5289519..5290103 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
KXE03_RS24305 (KXE03_24295) 5290144..5291244 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
KXE03_RS24315 (KXE03_24305) 5291651..5291956 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
KXE03_RS24320 (KXE03_24310) 5291968..5292246 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KXE03_RS29125 5292299..5292427 - 129 Protein_4815 integrase -
KXE03_RS24325 (KXE03_24315) 5292575..5294803 + 2229 WP_023086667.1 TonB-dependent receptor -
KXE03_RS24330 (KXE03_24320) 5294873..5295520 - 648 WP_003095021.1 carbonate dehydratase -
KXE03_RS24335 (KXE03_24325) 5295582..5296820 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T210550 WP_003113526.1 NZ_CP080007:c5292246-5291968 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T210550 NZ_CP104539:2734040-2734147 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT210550 WP_003113527.1 NZ_CP080007:c5291956-5291651 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT210550 NZ_CP104539:c2733990-2733927 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References