Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
Location | 2943510..2944012 | Replicon | chromosome |
Accession | NZ_CP079993 | ||
Organism | Escherichia coli strain EV36 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | U9YDH0 |
Locus tag | KYK84_RS14430 | Protein ID | WP_000767829.1 |
Coordinates | 2943510..2943764 (-) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | S1Q063 |
Locus tag | KYK84_RS14435 | Protein ID | WP_001259255.1 |
Coordinates | 2943761..2944012 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KYK84_RS14400 (2938525) | 2938525..2938752 | - | 228 | WP_000234896.1 | sulfurtransferase TusA | - |
KYK84_RS14405 (2938766) | 2938766..2939824 | - | 1059 | WP_000492339.1 | thiosulfate utilization transporter TsuA/YeeE | - |
KYK84_RS14410 (2940003) | 2940003..2941361 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
KYK84_RS14415 (2941351) | 2941351..2941413 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
KYK84_RS14420 (2941628) | 2941628..2942557 | - | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
KYK84_RS14425 (2942603) | 2942603..2943427 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
KYK84_RS14430 (2943510) | 2943510..2943764 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
KYK84_RS14435 (2943761) | 2943761..2944012 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
KYK84_RS14440 (2944295) | 2944295..2944345 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
KYK84_RS14445 (2944491) | 2944491..2945390 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
KYK84_RS14450 (2945396) | 2945396..2946700 | + | 1305 | WP_000009594.1 | histidinol dehydrogenase | - |
KYK84_RS14455 (2946697) | 2946697..2947767 | + | 1071 | WP_000108941.1 | histidinol-phosphate transaminase | - |
KYK84_RS14460 (2947767) | 2947767..2948834 | + | 1068 | WP_000080105.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T210537 WP_000767829.1 NZ_CP079993:c2943764-2943510 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T210537 NZ_CP104536:c4188450-4188277 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT210537 WP_001259255.1 NZ_CP079993:c2944012-2943761 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT210537 NZ_CP104536:c4188774-4188478 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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