Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
| Location | 4072647..4073341 | Replicon | chromosome |
| Accession | NC_005810 | ||
| Organism | Yersinia pestis biovar Microtus str. 91001 | ||
Toxin (Protein)
| Gene name | mqsR | Uniprot ID | A0A0E1NW62 |
| Locus tag | YP_RS18685 | Protein ID | WP_002214787.1 |
| Coordinates | 4073045..4073341 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | mqsA | Uniprot ID | Q666X1 |
| Locus tag | YP_RS18680 | Protein ID | WP_002209924.1 |
| Coordinates | 4072647..4073045 (-) | Length | 133 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| YP_RS18645 | 4067837..4068202 | + | 366 | WP_002209919.1 | hypothetical protein | - |
| YP_RS18650 | 4068215..4068451 | + | 237 | WP_002214792.1 | hypothetical protein | - |
| YP_RS18655 | 4068457..4068789 | + | 333 | WP_002214791.1 | hypothetical protein | - |
| YP_RS18660 | 4068971..4069171 | + | 201 | WP_002209920.1 | AlpA family transcriptional regulator | - |
| YP_RS24940 | 4069185..4069337 | - | 153 | WP_002209921.1 | hypothetical protein | - |
| YP_RS18670 | 4069330..4069656 | - | 327 | WP_002209922.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| YP_RS18675 | 4069956..4072247 | + | 2292 | WP_002209923.1 | toprim domain-containing protein | - |
| YP_RS18680 | 4072647..4073045 | - | 399 | WP_002209924.1 | type II toxin-antitoxin system MqsA family antitoxin | Antitoxin |
| YP_RS18685 | 4073045..4073341 | - | 297 | WP_002214787.1 | type II toxin-antitoxin system MqsR family toxin | Toxin |
| YP_RS18690 | 4073505..4073867 | - | 363 | WP_002209925.1 | helix-turn-helix domain-containing protein | - |
| YP_RS18695 | 4073930..4074190 | - | 261 | WP_002214785.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| YP_RS24765 | 4074788..4074982 | + | 195 | WP_042659217.1 | hypothetical protein | - |
| YP_RS18710 | 4075038..4076252 | - | 1215 | WP_002209929.1 | tyrosine-type recombinase/integrase | - |
| YP_RS18720 | 4076685..4078202 | - | 1518 | WP_002209930.1 | lysine--tRNA ligase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4063286..4074982 | 11696 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11319.12 Da Isoelectric Point: 7.8810
>T21050 WP_002214787.1 NC_005810:c4073341-4073045 [Yersinia pestis biovar Microtus str. 91001]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI
Download Length: 297 bp
>T21050 NC_005810:c4073341-4073045 [Yersinia pestis biovar Microtus str. 91001]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA
Antitoxin
Download Length: 133 a.a. Molecular weight: 14657.17 Da Isoelectric Point: 8.4923
>AT21050 WP_002209924.1 NC_005810:c4073045-4072647 [Yersinia pestis biovar Microtus str. 91001]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR
Download Length: 399 bp
>AT21050 NC_005810:c4073045-4072647 [Yersinia pestis biovar Microtus str. 91001]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E1NW62 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q666X1 |