Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1280692..1281214 Replicon chromosome
Accession NZ_CP079981
Organism Macrococcus bohemicus strain 19Msa0936

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KYI11_RS06600 Protein ID WP_188017413.1
Coordinates 1280692..1280964 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KYI11_RS06605 Protein ID WP_096076547.1
Coordinates 1280957..1281214 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYI11_RS06560 (KYI11_06570) 1276416..1276613 + 198 WP_219502392.1 hypothetical protein -
KYI11_RS06565 (KYI11_06575) 1276699..1276950 + 252 WP_086042489.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
KYI11_RS06570 (KYI11_06580) 1276950..1277210 + 261 WP_219502395.1 Txe/YoeB family addiction module toxin -
KYI11_RS06575 (KYI11_06585) 1277211..1277660 - 450 WP_219502398.1 GNAT family N-acetyltransferase -
KYI11_RS06580 (KYI11_06590) 1277902..1278483 + 582 WP_219502401.1 hypothetical protein -
KYI11_RS06585 (KYI11_06595) 1278493..1279383 + 891 WP_219502403.1 phosphotransferase -
KYI11_RS06590 (KYI11_06600) 1279415..1279900 + 486 WP_188017415.1 NUDIX domain-containing protein -
KYI11_RS06595 (KYI11_06605) 1279906..1280664 + 759 WP_219494766.1 hypothetical protein -
KYI11_RS06600 (KYI11_06610) 1280692..1280964 - 273 WP_188017413.1 Txe/YoeB family addiction module toxin Toxin
KYI11_RS06605 (KYI11_06615) 1280957..1281214 - 258 WP_096076547.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KYI11_RS06610 (KYI11_06620) 1281346..1282518 - 1173 WP_219502406.1 MFS transporter -
KYI11_RS06615 (KYI11_06625) 1283038..1283532 + 495 WP_188017403.1 isochorismatase family protein -
KYI11_RS12770 1283778..1283903 + 126 WP_262492331.1 hypothetical protein -
KYI11_RS06620 (KYI11_06630) 1283939..1285552 + 1614 WP_219502410.1 ABC-F type ribosomal protection protein -
KYI11_RS06625 (KYI11_06635) 1285675..1286142 + 468 WP_219502413.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10603.39 Da        Isoelectric Point: 10.0864

>T210443 WP_188017413.1 NZ_CP079981:c1280964-1280692 [Macrococcus bohemicus]
MPKKKILFNSSGFEDYTYWQTKDKTVSKKINKLIKSIMIDGANVGIGKPEKLLGNYTGCYSRRITHEHRLVYKIEDDSIC
ILQCRFHYKR

Download         Length: 273 bp

>T210443 NZ_CP104521:c4524820-4524713 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9718.81 Da        Isoelectric Point: 4.2805

>AT210443 WP_096076547.1 NZ_CP079981:c1281214-1280957 [Macrococcus bohemicus]
MKVTTYSNARSNFRKIIDIVNEDCEPYTITTNTHNAVILSEHDYNSMIETLYLQSTPANAERLQKAIDESIDKNNLLQVE
IDLDA

Download         Length: 258 bp

>AT210443 NZ_CP104521:4524877-4524934 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References