Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe(toxin)
Location 1276699..1277210 Replicon chromosome
Accession NZ_CP079981
Organism Macrococcus bohemicus strain 19Msa0936

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KYI11_RS06570 Protein ID WP_219502395.1
Coordinates 1276950..1277210 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KYI11_RS06565 Protein ID WP_086042489.1
Coordinates 1276699..1276950 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYI11_RS06530 (KYI11_06540) 1271868..1272383 - 516 WP_219502378.1 DUF402 domain-containing protein -
KYI11_RS06535 (KYI11_06545) 1272497..1272955 + 459 WP_219502380.1 GNAT family N-acetyltransferase -
KYI11_RS06540 (KYI11_06550) 1272976..1273434 + 459 WP_219502382.1 NUDIX domain-containing protein -
KYI11_RS06545 (KYI11_06555) 1273453..1274220 + 768 WP_219502384.1 hypothetical protein -
KYI11_RS06550 (KYI11_06560) 1274229..1275107 + 879 WP_219502386.1 alpha/beta hydrolase -
KYI11_RS06555 (KYI11_06565) 1275263..1276000 + 738 WP_219502389.1 class I SAM-dependent methyltransferase -
KYI11_RS06560 (KYI11_06570) 1276416..1276613 + 198 WP_219502392.1 hypothetical protein -
KYI11_RS06565 (KYI11_06575) 1276699..1276950 + 252 WP_086042489.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KYI11_RS06570 (KYI11_06580) 1276950..1277210 + 261 WP_219502395.1 Txe/YoeB family addiction module toxin Toxin
KYI11_RS06575 (KYI11_06585) 1277211..1277660 - 450 WP_219502398.1 GNAT family N-acetyltransferase -
KYI11_RS06580 (KYI11_06590) 1277902..1278483 + 582 WP_219502401.1 hypothetical protein -
KYI11_RS06585 (KYI11_06595) 1278493..1279383 + 891 WP_219502403.1 phosphotransferase -
KYI11_RS06590 (KYI11_06600) 1279415..1279900 + 486 WP_188017415.1 NUDIX domain-containing protein -
KYI11_RS06595 (KYI11_06605) 1279906..1280664 + 759 WP_219494766.1 hypothetical protein -
KYI11_RS06600 (KYI11_06610) 1280692..1280964 - 273 WP_188017413.1 Txe/YoeB family addiction module toxin -
KYI11_RS06605 (KYI11_06615) 1280957..1281214 - 258 WP_096076547.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(21-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-59)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.94 Da        Isoelectric Point: 10.2531

>T210442 WP_219502395.1 NZ_CP079981:1276950-1277210 [Macrococcus bohemicus]
MYKIVMKSSVKKDLKKIKNTHLETNFLKIIKQLKENPYNNNHSFEKIIPPIKGFYSRRINVQHRVVYTVNDEDKIATIYS
AYGHYE

Download         Length: 261 bp

>T210442 NZ_CP104521:c4410413-4410138 [Escherichia coli]
ATGAGAACCCAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAATCTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTT
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9590.65 Da        Isoelectric Point: 4.0373

>AT210442 WP_086042489.1 NZ_CP079981:1276699-1276950 [Macrococcus bohemicus]
MNTYTPTSARKDFFNIIKSVNEDSKEIYIAPTKIGEKGAVLVGEDDWNAIQETLFLLEKGIAYQIEQRKDEEEIDFDSTW
DNI

Download         Length: 252 bp

>AT210442 NZ_CP104521:c4410141-4409782 [Escherichia coli]
ATGATCAAACTGAAGACACCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGTATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACATTACGCTATCCAGAATCGCTGAGTGAACGCCTTACTAATGCGGCTGCGCAGCAACAAGTCTCTGTAAATACTTA
TATTATTGAAACGCTAAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References