Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe(toxin)
Location 1099966..1100477 Replicon chromosome
Accession NZ_CP079965
Organism Macrococcus caseolyticus strain 19Msa0687

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KYI09_RS05575 Protein ID WP_101040676.1
Coordinates 1099966..1100226 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KYI09_RS05580 Protein ID WP_086042489.1
Coordinates 1100226..1100477 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYI09_RS05535 (KYI09_05540) 1095261..1095782 - 522 WP_219520600.1 GrpB family protein -
KYI09_RS05540 (KYI09_05545) 1095965..1096221 + 257 Protein_1090 type II toxin-antitoxin system Phd/YefM family antitoxin -
KYI09_RS05545 (KYI09_05550) 1096214..1096485 + 272 Protein_1091 Txe/YoeB family addiction module toxin -
KYI09_RS05550 (KYI09_05555) 1096503..1097270 - 768 WP_219520603.1 hypothetical protein -
KYI09_RS05555 (KYI09_05560) 1097276..1097761 - 486 WP_101030758.1 NUDIX domain-containing protein -
KYI09_RS05560 (KYI09_05565) 1097793..1098683 - 891 WP_219520604.1 phosphotransferase -
KYI09_RS05565 (KYI09_05570) 1098693..1099433 - 741 WP_219520606.1 hypothetical protein -
KYI09_RS05570 (KYI09_05575) 1099516..1099965 + 450 WP_219520608.1 GNAT family N-acetyltransferase -
KYI09_RS05575 (KYI09_05580) 1099966..1100226 - 261 WP_101040676.1 Txe/YoeB family addiction module toxin Toxin
KYI09_RS05580 (KYI09_05585) 1100226..1100477 - 252 WP_086042489.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KYI09_RS05585 (KYI09_05590) 1100562..1101026 - 465 WP_101040674.1 NUDIX domain-containing protein -
KYI09_RS05590 (KYI09_05595) 1101493..1101879 - 387 WP_050742435.1 sporulation protein -
KYI09_RS05595 (KYI09_05600) 1102040..1103044 + 1005 WP_219520610.1 cation diffusion facilitator family transporter -
KYI09_RS05600 (KYI09_05605) 1103092..1103280 + 189 WP_041635987.1 2-hydroxymuconate tautomerase -
KYI09_RS05605 (KYI09_05610) 1103311..1104252 - 942 WP_219520612.1 LCP family protein -
KYI09_RS05610 (KYI09_05615) 1104374..1104877 + 504 WP_219520614.1 peptide-methionine (S)-S-oxide reductase MsrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-59)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10287.96 Da        Isoelectric Point: 10.2531

>T210440 WP_101040676.1 NZ_CP079965:c1100226-1099966 [Macrococcus caseolyticus]
MYKVVMKSSVKKDLKKIKNTHLETNFLKIIKQLKENPYNNNHSFEKLIPPIKGFYSRRLNVQHRVVYTVNDEDKIVTIYS
AYGHYE

Download         Length: 261 bp

>T210440 NZ_CP104521:4076254-4076718 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGCGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9590.65 Da        Isoelectric Point: 4.0373

>AT210440 WP_086042489.1 NZ_CP079965:c1100477-1100226 [Macrococcus caseolyticus]
MNTYTPTSARKDFFNIIKSVNEDSKEIYIAPTKIGEKGAVLVGEDDWNAIQETLFLLEKGIAYQIEQRKDEEEIDFDSTW
DNI

Download         Length: 252 bp

>AT210440 NZ_CP104521:4075919-4076254 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References