Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1027153..1027675 Replicon chromosome
Accession NZ_CP079955
Organism Macrococcus sp. 19Msa1099

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KYI10_RS05200 Protein ID WP_219494767.1
Coordinates 1027153..1027425 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KYI10_RS05205 Protein ID WP_096076547.1
Coordinates 1027418..1027675 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYI10_RS05155 (KYI10_05150) 1022377..1022517 - 141 WP_186309442.1 hypothetical protein -
KYI10_RS05160 (KYI10_05155) 1022610..1023074 + 465 WP_219494760.1 NUDIX domain-containing protein -
KYI10_RS05165 (KYI10_05160) 1023160..1023411 + 252 WP_086042489.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
KYI10_RS05170 (KYI10_05165) 1023411..1023671 + 261 WP_219494761.1 Txe/YoeB family addiction module toxin -
KYI10_RS05175 (KYI10_05170) 1023672..1024121 - 450 WP_219494762.1 GNAT family N-acetyltransferase -
KYI10_RS05180 (KYI10_05175) 1024204..1024944 + 741 WP_219494763.1 hypothetical protein -
KYI10_RS05185 (KYI10_05180) 1024954..1025766 + 813 WP_219494764.1 phosphotransferase -
KYI10_RS05190 (KYI10_05185) 1025876..1026361 + 486 WP_219494765.1 NUDIX domain-containing protein -
KYI10_RS05195 (KYI10_05190) 1026367..1027125 + 759 WP_219494766.1 hypothetical protein -
KYI10_RS05200 (KYI10_05195) 1027153..1027425 - 273 WP_219494767.1 Txe/YoeB family addiction module toxin Toxin
KYI10_RS05205 (KYI10_05200) 1027418..1027675 - 258 WP_096076547.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KYI10_RS05210 (KYI10_05205) 1027806..1028978 - 1173 WP_219494768.1 MFS transporter -
KYI10_RS05215 (KYI10_05210) 1029027..1029257 - 231 WP_219495238.1 hypothetical protein -
KYI10_RS05220 (KYI10_05215) 1029496..1029990 + 495 WP_219494769.1 isochorismatase family cysteine hydrolase -
KYI10_RS05225 (KYI10_05220) 1030180..1030611 + 432 WP_219495240.1 hypothetical protein -
KYI10_RS05230 (KYI10_05225) 1030807..1032069 + 1263 WP_219494771.1 Y-family DNA polymerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10652.46 Da        Isoelectric Point: 10.0258

>T210438 WP_219494767.1 NZ_CP079955:c1027425-1027153 [Macrococcus sp. 19Msa1099]
MPKKKILFYSSGFEDYTYWQTKDKTVSKKINKLIKSIMIDGANVGIGKPEKLLGNYTGCYSRRITHEHRLVYKIEDDSIC
ILQCRFHYKR

Download         Length: 273 bp

>T210438 NZ_CP104521:c3670715-3670308 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9718.81 Da        Isoelectric Point: 4.2805

>AT210438 WP_096076547.1 NZ_CP079955:c1027675-1027418 [Macrococcus sp. 19Msa1099]
MKVTTYSNARSNFRKIIDIVNEDCEPYTITTNTHNAVILSEHDYNSMIETLYLQSTPANAERLQKAIDESIDKNNLLQVE
IDLDA

Download         Length: 258 bp

>AT210438 NZ_CP104521:c3670962-3670696 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References