Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe(toxin)
Location 1023160..1023671 Replicon chromosome
Accession NZ_CP079955
Organism Macrococcus sp. 19Msa1099

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KYI10_RS05170 Protein ID WP_219494761.1
Coordinates 1023411..1023671 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KYI10_RS05165 Protein ID WP_086042489.1
Coordinates 1023160..1023411 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYI10_RS05130 (KYI10_05125) 1018813..1019316 - 504 WP_219494756.1 peptide-methionine (S)-S-oxide reductase MsrA -
KYI10_RS05135 (KYI10_05130) 1019438..1020379 + 942 WP_219494757.1 LCP family protein -
KYI10_RS05140 (KYI10_05135) 1020410..1020598 - 189 WP_041635987.1 2-hydroxymuconate tautomerase -
KYI10_RS05145 (KYI10_05140) 1020647..1021651 - 1005 WP_219494758.1 cation diffusion facilitator family transporter -
KYI10_RS05150 (KYI10_05145) 1021812..1022198 + 387 WP_219494759.1 sporulation protein -
KYI10_RS05155 (KYI10_05150) 1022377..1022517 - 141 WP_186309442.1 hypothetical protein -
KYI10_RS05160 (KYI10_05155) 1022610..1023074 + 465 WP_219494760.1 NUDIX domain-containing protein -
KYI10_RS05165 (KYI10_05160) 1023160..1023411 + 252 WP_086042489.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KYI10_RS05170 (KYI10_05165) 1023411..1023671 + 261 WP_219494761.1 Txe/YoeB family addiction module toxin Toxin
KYI10_RS05175 (KYI10_05170) 1023672..1024121 - 450 WP_219494762.1 GNAT family N-acetyltransferase -
KYI10_RS05180 (KYI10_05175) 1024204..1024944 + 741 WP_219494763.1 hypothetical protein -
KYI10_RS05185 (KYI10_05180) 1024954..1025766 + 813 WP_219494764.1 phosphotransferase -
KYI10_RS05190 (KYI10_05185) 1025876..1026361 + 486 WP_219494765.1 NUDIX domain-containing protein -
KYI10_RS05195 (KYI10_05190) 1026367..1027125 + 759 WP_219494766.1 hypothetical protein -
KYI10_RS05200 (KYI10_05195) 1027153..1027425 - 273 WP_219494767.1 Txe/YoeB family addiction module toxin -
KYI10_RS05205 (KYI10_05200) 1027418..1027675 - 258 WP_096076547.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-59)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10307.01 Da        Isoelectric Point: 10.3592

>T210437 WP_219494761.1 NZ_CP079955:1023411-1023671 [Macrococcus sp. 19Msa1099]
MYKVVMKSSVKKDLKKIKNTHLETNFLKIIKQLKENPYNNNHSFEKLIPPIKGFYSRRLNVQHRVVYTVNDEDKIVTIYS
AYGRYE

Download         Length: 261 bp

>T210437 NZ_CP104521:c3223304-3222906 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAACATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTAACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9590.65 Da        Isoelectric Point: 4.0373

>AT210437 WP_086042489.1 NZ_CP079955:1023160-1023411 [Macrococcus sp. 19Msa1099]
MNTYTPTSARKDFFNIIKSVNEDSKEIYIAPTKIGEKGAVLVGEDDWNAIQETLFLLEKGIAYQIEQRKDEEEIDFDSTW
DNI

Download         Length: 252 bp

>AT210437 NZ_CP104521:c3223531-3223304 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References