210435

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1226360..1226882 Replicon chromosome
Accession NZ_CP079950
Organism Macrococcus caseolyticus strain 19Msa0287

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KYI08_RS06360 Protein ID WP_086038670.1
Coordinates 1226360..1226632 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KYI08_RS06365 Protein ID WP_086038671.1
Coordinates 1226625..1226882 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYI08_RS06330 (KYI08_06330) 1222392..1222778 + 387 WP_157819678.1 sporulation protein -
KYI08_RS06335 (KYI08_06335) 1222879..1223328 - 450 WP_101030762.1 GNAT family N-acetyltransferase -
KYI08_RS06340 (KYI08_06340) 1223411..1224151 + 741 WP_101030760.1 hypothetical protein -
KYI08_RS06345 (KYI08_06345) 1224161..1225051 + 891 WP_086038667.1 phosphotransferase -
KYI08_RS06350 (KYI08_06350) 1225083..1225568 + 486 WP_086038668.1 NUDIX domain-containing protein -
KYI08_RS06355 (KYI08_06355) 1225583..1226332 + 750 WP_086038669.1 hypothetical protein -
KYI08_RS06360 (KYI08_06360) 1226360..1226632 - 273 WP_086038670.1 Txe/YoeB family addiction module toxin Toxin
KYI08_RS06365 (KYI08_06365) 1226625..1226882 - 258 WP_086038671.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KYI08_RS06370 (KYI08_06370) 1227013..1228185 - 1173 WP_086038672.1 MFS transporter -
KYI08_RS06375 (KYI08_06375) 1228370..1228984 - 615 WP_086038673.1 DJ-1/PfpI family protein -
KYI08_RS06380 (KYI08_06380) 1229205..1230164 - 960 WP_101057760.1 IS30 family transposase -
KYI08_RS06385 (KYI08_06385) 1230756..1231859 + 1104 WP_076688030.1 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1229205..1230164 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10684.42 Da        Isoelectric Point: 9.7524

>T210435 WP_086038670.1 NZ_CP079950:c1226632-1226360 [Macrococcus caseolyticus]
MSKKKILFYSSGFEDYTYWQTNDKTVLKKINKLIKSIMIDGANEGIGKPEKLLGNYTGCYSRRITHEHRLVYKIEDDSIC
ILQCRFHYKR

Download         Length: 273 bp

>T210435 NZ_CP104521:c2743045-2742791 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATTATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9738.84 Da        Isoelectric Point: 4.0936

>AT210435 WP_086038671.1 NZ_CP079950:c1226882-1226625 [Macrococcus caseolyticus]
MKVTTYSNARSNFRKIIDIVNEDCEPYTITTNTHNAVILSEQDYNSMIETLYLQSTPANAERLQKAIDESIDKNNLLEVE
IDLDV

Download         Length: 258 bp

>AT210435 NZ_CP104521:c2743293-2743042 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References