Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 6630..7281 | Replicon | plasmid pAB1 |
| Accession | NZ_CP079933 | ||
| Organism | Acinetobacter baumannii strain 17978UN | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | V2UF49 |
| Locus tag | KZA74_RS19335 | Protein ID | WP_000269909.1 |
| Coordinates | 6925..7281 (-) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | KZA74_RS19330 | Protein ID | WP_001140621.1 |
| Coordinates | 6630..6932 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZA74_RS19300 (KZA74_19310) | 2346..2858 | - | 513 | WP_001089572.1 | SMI1/KNR4 family protein | - |
| KZA74_RS19305 (KZA74_19315) | 2897..3415 | - | 519 | WP_000447196.1 | tetratricopeptide repeat protein | - |
| KZA74_RS19310 (KZA74_19320) | 3631..4242 | - | 612 | WP_000571899.1 | recombinase family protein | - |
| KZA74_RS19315 (KZA74_19325) | 4440..5153 | - | 714 | WP_061855755.1 | HEPN domain-containing protein | - |
| KZA74_RS19320 (KZA74_19330) | 5160..6290 | - | 1131 | WP_000085720.1 | DUF262 domain-containing protein | - |
| KZA74_RS19325 (KZA74_19335) | 6428..6637 | - | 210 | WP_000069472.1 | hypothetical protein | - |
| KZA74_RS19330 (KZA74_19340) | 6630..6932 | - | 303 | WP_001140621.1 | XRE family transcriptional regulator | Antitoxin |
| KZA74_RS19335 (KZA74_19345) | 6925..7281 | - | 357 | WP_000269909.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KZA74_RS19340 (KZA74_19350) | 8295..8435 | - | 141 | Protein_10 | transposase | - |
| KZA74_RS19345 (KZA74_19355) | 8634..9002 | - | 369 | WP_000139283.1 | LysR family transcriptional regulator | - |
| KZA74_RS19350 (KZA74_19360) | 9967..10923 | + | 957 | WP_000786840.1 | replication initiation protein RepM | - |
| KZA74_RS19355 (KZA74_19365) | 10916..11470 | + | 555 | WP_001096621.1 | plasmid replication DNA-binding protein | - |
| KZA74_RS19360 (KZA74_19370) | 11491..11634 | + | 144 | WP_001125249.1 | hypothetical protein | - |
| KZA74_RS19365 (KZA74_19375) | 11817..12206 | - | 390 | WP_000078281.1 | tautomerase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..13409 | 13409 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 13515.49 Da Isoelectric Point: 6.4631
>T210410 WP_000269909.1 NZ_CP079933:c7281-6925 [Acinetobacter baumannii]
MWTVITTDLFNEWLVQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYELHLSTLGDQSNG
MWTVITTDLFNEWLVQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYELHLSTLGDQSNG
Download Length: 357 bp
>T210410 NZ_CP104516:c2798004-2797618 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTAGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCCGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTAGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCCGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11179.02 Da Isoelectric Point: 7.3198
>AT210410 WP_001140621.1 NZ_CP079933:c6932-6630 [Acinetobacter baumannii]
MAKTLQELLASRSPESQARIQKMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
MAKTLQELLASRSPESQARIQKMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
Download Length: 303 bp
>AT210410 NZ_CP104516:c2798543-2798034 [Escherichia coli]
ATGGCATATCTGAAATTGATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGA
AGATAGCCTTTACTCTATGAAATTTGGTCCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGTATTG
GTGACTACTGGTACAACCTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGAC
GAGGTCTTTGATGAGTTGAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATT
TGATCTCGCAAACATGACGCATTTAGAAAGCGTTTGTCCAGAGTGGCACAATCCTGGCAATTCTCGTAAGCCTATAGACC
TGAAAGAAATGCTGATCAGTGAGGGTAAAAGCGAGGATGAGGCTAATCGTATAATTGGCAAAATGGAAGAATCTCAGAAA
CTTAAGGAATTTTCTTTGCAATTATCATGA
ATGGCATATCTGAAATTGATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGA
AGATAGCCTTTACTCTATGAAATTTGGTCCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGTATTG
GTGACTACTGGTACAACCTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGAC
GAGGTCTTTGATGAGTTGAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATT
TGATCTCGCAAACATGACGCATTTAGAAAGCGTTTGTCCAGAGTGGCACAATCCTGGCAATTCTCGTAAGCCTATAGACC
TGAAAGAAATGCTGATCAGTGAGGGTAAAAGCGAGGATGAGGCTAATCGTATAATTGGCAAAATGGAAGAATCTCAGAAA
CTTAAGGAATTTTCTTTGCAATTATCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|