Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1790206..1790708 | Replicon | chromosome |
| Accession | NZ_CP079924 | ||
| Organism | Escherichia sp. TC-EC600-tetX4 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | KXD89_RS08485 | Protein ID | WP_000767829.1 |
| Coordinates | 1790454..1790708 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | KXD89_RS08480 | Protein ID | WP_001259255.1 |
| Coordinates | 1790206..1790457 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KXD89_RS08455 (1785384) | 1785384..1786451 | - | 1068 | WP_000080105.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| KXD89_RS08460 (1786451) | 1786451..1787521 | - | 1071 | WP_000108941.1 | histidinol-phosphate transaminase | - |
| KXD89_RS08465 (1787518) | 1787518..1788822 | - | 1305 | WP_000009594.1 | histidinol dehydrogenase | - |
| KXD89_RS08470 (1788828) | 1788828..1789727 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| KXD89_RS08475 (1789873) | 1789873..1789923 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| KXD89_RS08480 (1790206) | 1790206..1790457 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| KXD89_RS08485 (1790454) | 1790454..1790708 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| KXD89_RS08490 (1790791) | 1790791..1791615 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| KXD89_RS08495 (1791661) | 1791661..1792590 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| KXD89_RS08500 (1792805) | 1792805..1792867 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| KXD89_RS08505 (1792857) | 1792857..1794215 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| KXD89_RS08510 (1794394) | 1794394..1795452 | + | 1059 | WP_000492339.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| KXD89_RS08515 (1795466) | 1795466..1795693 | + | 228 | WP_000234896.1 | sulfurtransferase TusA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T210380 WP_000767829.1 NZ_CP079924:1790454-1790708 [Escherichia sp. TC-EC600-tetX4]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T210380 NZ_CP079924:1790454-1790708 [Escherichia sp. TC-EC600-tetX4]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT210380 WP_001259255.1 NZ_CP079924:1790206-1790457 [Escherichia sp. TC-EC600-tetX4]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT210380 NZ_CP079924:1790206-1790457 [Escherichia sp. TC-EC600-tetX4]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|