210371

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1557907..1558419 Replicon chromosome
Accession NZ_CP079923
Organism Streptococcus pneumoniae strain Rx1

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag KZH43_RS07695 Protein ID WP_000924721.1
Coordinates 1557907..1558161 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag KZH43_RS07700 Protein ID WP_000388572.1
Coordinates 1558165..1558419 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZH43_RS07680 (KZH43_07680) 1555008..1555322 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
KZH43_RS07685 (KZH43_07685) 1555347..1555973 - 627 WP_000775044.1 guanylate kinase -
KZH43_RS07690 (KZH43_07690) 1556103..1557716 - 1614 WP_000404940.1 ribonuclease Y -
KZH43_RS07695 (KZH43_07695) 1557907..1558161 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
KZH43_RS07700 (KZH43_07700) 1558165..1558419 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KZH43_RS07705 (KZH43_07705) 1558657..1559754 - 1098 WP_000156355.1 nucleotidyltransferase -
KZH43_RS07710 (KZH43_07710) 1559764..1560510 - 747 WP_000605157.1 class I SAM-dependent methyltransferase -
KZH43_RS07715 (KZH43_07715) 1560613..1560966 - 354 WP_001003001.1 ribosome silencing factor -
KZH43_RS07720 (KZH43_07720) 1560979..1561479 - 501 WP_000844717.1 cysteine hydrolase family protein -
KZH43_RS07725 (KZH43_07725) 1561480..1562073 - 594 WP_000121655.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
KZH43_RS07730 (KZH43_07730) 1562073..1562702 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
KZH43_RS07735 (KZH43_07735) 1562754..1563065 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T210371 WP_000924721.1 NZ_CP079923:c1558161-1557907 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T210371 NZ_CP104509:c950911-950633 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT210371 WP_000388572.1 NZ_CP079923:c1558419-1558165 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT210371 NZ_CP104509:c951174-950914 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References