Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-RelB |
| Location | 1567821..1568333 | Replicon | chromosome |
| Accession | NZ_CP079922 | ||
| Organism | Streptococcus pneumoniae strain R36A | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | Q8DNR3 |
| Locus tag | KZB15_RS07710 | Protein ID | WP_000924721.1 |
| Coordinates | 1567821..1568075 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | K0ZY22 |
| Locus tag | KZB15_RS07715 | Protein ID | WP_000388572.1 |
| Coordinates | 1568079..1568333 (-) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZB15_RS07695 (KZB15_07705) | 1564922..1565236 | - | 315 | WP_000979235.1 | DNA-directed RNA polymerase subunit omega | - |
| KZB15_RS07700 (KZB15_07710) | 1565261..1565887 | - | 627 | WP_000775044.1 | guanylate kinase | - |
| KZB15_RS07705 (KZB15_07715) | 1566017..1567630 | - | 1614 | WP_000404940.1 | ribonuclease Y | - |
| KZB15_RS07710 (KZB15_07720) | 1567821..1568075 | - | 255 | WP_000924721.1 | Txe/YoeB family addiction module toxin | Toxin |
| KZB15_RS07715 (KZB15_07725) | 1568079..1568333 | - | 255 | WP_000388572.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KZB15_RS07720 (KZB15_07730) | 1568571..1569668 | - | 1098 | WP_000156355.1 | nucleotidyltransferase | - |
| KZB15_RS07725 (KZB15_07735) | 1569678..1570424 | - | 747 | WP_000605157.1 | class I SAM-dependent methyltransferase | - |
| KZB15_RS07730 (KZB15_07740) | 1570527..1570880 | - | 354 | WP_001003001.1 | ribosome silencing factor | - |
| KZB15_RS07735 (KZB15_07745) | 1570893..1571393 | - | 501 | WP_000844717.1 | cysteine hydrolase family protein | - |
| KZB15_RS07740 (KZB15_07750) | 1571394..1571987 | - | 594 | WP_000121655.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK | - |
| KZB15_RS07745 (KZB15_07755) | 1571987..1572616 | - | 630 | WP_000151313.1 | nicotinate-nucleotide adenylyltransferase | - |
| KZB15_RS07750 (KZB15_07760) | 1572668..1572979 | - | 312 | WP_000060169.1 | ribosome assembly RNA-binding protein YhbY | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10115.55 Da Isoelectric Point: 7.9716
>T210367 WP_000924721.1 NZ_CP079922:c1568075-1567821 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY
Download Length: 255 bp
>T210367 NZ_CP104509:184142-184528 [Escherichia coli]
GTGCTTGCCCCAACTGGACCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATCTCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA
GTGCTTGCCCCAACTGGACCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATCTCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9706.00 Da Isoelectric Point: 4.8430
>AT210367 WP_000388572.1 NZ_CP079922:c1568333-1568079 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE
Download Length: 255 bp
>AT210367 NZ_CP104509:183603-184112 [Escherichia coli]
ATGGCATATCTGAAATTGATGAAGCTGCTCTATCTGTCTAACCGCCAGTCGATTTTGAAGCATGGCAGGATGATCGGCGA
AGATAGCCTTTACTCTATGAAATTTGGACCAGTCATGTCGAATACGCTGAACTTGATTCGCGGTAAGGCTGAAGGCATTG
GTGACTACTGGTACAACTTGATAGAGACGAACGGGCATAATGTATCGTTGCGTTCAGATCCGAGGGAAATGGATGCAGAC
GAGGTCTTTGATGAATTGAGTCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCGGTATGGGCATATGAACCGATT
TGATCTCGCAAATATGACGCATTTAGAAAGCGTTTGTCCAGAGTGGCACGATCCTGGCAATTCTCGTAAGCCTATAGACC
TGAAAGAAATGCTGATCAGTGAGGGTAAAAGCGAGGATGAGGCTAATCGCATAATTGGCAAAATGGAAGAATCTCAGAAA
CTTAAGGAATTTTCTTTGCAATTATCATGA
ATGGCATATCTGAAATTGATGAAGCTGCTCTATCTGTCTAACCGCCAGTCGATTTTGAAGCATGGCAGGATGATCGGCGA
AGATAGCCTTTACTCTATGAAATTTGGACCAGTCATGTCGAATACGCTGAACTTGATTCGCGGTAAGGCTGAAGGCATTG
GTGACTACTGGTACAACTTGATAGAGACGAACGGGCATAATGTATCGTTGCGTTCAGATCCGAGGGAAATGGATGCAGAC
GAGGTCTTTGATGAATTGAGTCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCGGTATGGGCATATGAACCGATT
TGATCTCGCAAATATGACGCATTTAGAAAGCGTTTGTCCAGAGTGGCACGATCCTGGCAATTCTCGTAAGCCTATAGACC
TGAAAGAAATGCTGATCAGTGAGGGTAAAAGCGAGGATGAGGCTAATCGCATAATTGGCAAAATGGAAGAATCTCAGAAA
CTTAAGGAATTTTCTTTGCAATTATCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0B7LEN4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | K0ZY22 |