Detailed information of TA system TA210345

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3861963..3862221
• Replicon: chromosome
• Accession: NZ_CP079891
• Organism: Escherichia fergusonii strain 5zf15-2-1

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: KYD87_RS19165
• Protein ID: WP_046082123.1
• Coordinates: 3862069..3862221 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3861963..3862020 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KYD87_RS19135	3857767..3858708	-	942	WP_000767324.1	bifunctional riboflavin kinase/FAD synthetase	-
KYD87_RS19140	3858716..3858934	-	219	WP_012599853.1	DUF2575 family protein	-
KYD87_RS19145	3859037..3859300	+	264	WP_001274021.1	30S ribosomal protein S20	-
KYD87_RS19150	3859396..3860295	-	900	WP_000019049.1	transcriptional activator NhaR	-
KYD87_RS19155	3860363..3861529	-	1167	WP_000681374.1	Na+/H+ antiporter NhaA	-
KYD87_RS19160	3861724..3861894	+	171	WP_159424275.1	hypothetical protein	-
-	3861963..3862020	-	58	-	-	Antitoxin
KYD87_RS19165	3862069..3862221	+	153	WP_046082123.1	type I toxin-antitoxin system toxin MokC	Toxin
KYD87_RS19170	3862326..3863456	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
KYD87_RS19175	3863545..3865461	-	1917	WP_000516135.1	molecular chaperone DnaK	-
KYD87_RS19180	3865969..3866535	+	567	WP_000528529.1	acetate uptake transporter	-
KYD87_RS19185	3866569..3867156	-	588	WP_002431696.1	molybdopterin adenylyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5511.59 Da
• Isoelectric Point: 7.1312

>T210345 WP_046082123.1 NZ_CP079891:3862069-3862221 [Escherichia fergusonii]
MKQHKAIIVALIVICITAVVVALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T210345 NZ_CP104503:c587605-587336 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACACGATT
ACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTACATCCGTTAA
GCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAATGGCGATGCA
TACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT210345 NZ_CP079891:c3862020-3861963 [Escherichia fergusonii]
GTTCTGCATATAGGGGGCCTCGGGTTGATAGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin